Technology Process of Pyridine, 1,2,3,6-tetrahydro-6-(4-pentenyl)-1-(phenylmethyl)-2-propyl-,
(2S,6R)-
There total 9 articles about Pyridine, 1,2,3,6-tetrahydro-6-(4-pentenyl)-1-(phenylmethyl)-2-propyl-,
(2S,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,6R)-N-(2-nitrobenzenesulfonyl)-6-pent-4-enyl-2-propyl-1,2,3,6-tetrahydropyridine;
With
potassium carbonate; thiophenol;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 2h;
benzyl bromide;
With
tetra-(n-butyl)ammonium iodide;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 1h;
DOI:10.1021/ol0474610
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 83 percent / PPh3; DIAD / tetrahydrofuran / 72 h / 20 °C
2.1: 96 percent / ethylene / Grubbs I catalyst / CH2Cl2 / 24 h / 50 °C
3.1: K2CO3; thiophenol / dimethylformamide / 2 h / 80 °C
3.2: 95 percent / TBAI / dimethylformamide / 1 h / 80 °C
With
ethene; di-isopropyl azodicarboxylate; potassium carbonate; thiophenol; triphenylphosphine;
Grubbs catalyst first generation;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
1.1: Mitsunobu reaction;
DOI:10.1021/ol0474610
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 96 percent / ethylene / Grubbs I catalyst / CH2Cl2 / 24 h / 50 °C
2.1: K2CO3; thiophenol / dimethylformamide / 2 h / 80 °C
2.2: 95 percent / TBAI / dimethylformamide / 1 h / 80 °C
With
ethene; potassium carbonate; thiophenol;
Grubbs catalyst first generation;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0474610
