6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:850628-81-8
Molecular Formula:C₁₆H₁₉N₃O₂S
Molecular Weight:317.412
Hs Code.:

Synonyms:6-acetyl-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one;

Suppliers and Price of 6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Chemical Property:

PSA：90.15000
LogP:3.13950

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one

There total 5 articles about 6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 362656-25-5
6-bromo-8-cyclopentyl-5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 97674-02-7
tributyl(1-ethoxyvinyl)stannane

: 850628-81-8
6-acetyl-8-cyclopentyl-5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 5h;
DOI:10.1021/jm049355+

Reference yield:

: C₁₈H₂₃N₃O₂S

: 850628-81-8
6-acetyl-8-cyclopentyl-5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: With hydrogenchloride; water; for 0.333333h; Cooling;

Reference yield:

: 362656-23-3
8?cyclopentyl?5?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one

: 850628-81-8
6-acetyl-8-cyclopentyl-5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / N-bromosuccinimide; benzoylperoxide / dimethylformamide / 20 °C

2: 52 percent / Pd(PPh₃)4 / toluene / 5 h / 110 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In N,N-dimethyl-formamide; toluene; 2: Stille coupling;
DOI:10.1021/jm049355+