6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:850628-86-3
Molecular Formula:C16H19N3O3S
Molecular Weight:333.411
Hs Code.:

Synonyms:6-acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one;

Suppliers and Price of 6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Chemical Property:

PSA：101.13000
LogP:3.02070

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

There total 7 articles about 6-Acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 850628-81-8
6-acetyl-8-cyclopentyl-5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 850628-86-3
6-acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With 2-benzylsulfonyl-3-phenyloxaziridine; In dichloromethane;
DOI:10.1021/jm049355+

Reference yield: 76.3%

: 1556-18-9
cyclopentyl iodide

: 6-acetyl-5-methyl-2-methylsulfinylpyrido[2,3-d]pyrimidin-7(8H)-one

: 850628-86-3
6-acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: 6-acetyl-5-methyl-2-methylsulfinylpyrido[2,3-d]pyrimidin-7(8H)-one; With potassium tert-butylate; sodium hydride; In N,N-dimethyl-formamide; at 55 ℃; for 0.5h; Inert atmosphere;

cyclopentyl iodide; In N,N-dimethyl-formamide; at 55 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 362656-23-3
8?cyclopentyl?5?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one

: 850628-86-3
6-acetyl-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / N-bromosuccinimide; benzoylperoxide / dimethylformamide / 20 °C

2: 52 percent / Pd(PPh₃)4 / toluene / 5 h / 110 °C

3: 81 percent / 2-benzylsulfonyl-3-phenyloxaziradine / CH₂Cl₂

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-benzylsulfonyl-3-phenyloxaziridine; dibenzoyl peroxide; In dichloromethane; N,N-dimethyl-formamide; toluene; 2: Stille coupling;
DOI:10.1021/jm049355+