trans-Bis(methylammine)dichloroplatinum(II)

Base Information

• Chemical Name: trans-Bis(methylammine)dichloroplatinum(II)
• CAS No.: 52691-24-4
• Molecular Formula: C₆H₁₄Cl₂N₂Pt
• Molecular Weight: 380.177
• European Community (EC) Number: 633-413-5
• DSSTox Substance ID: DTXSID10977416
• Mol file: 52691-24-4.mol

Synonyms:(cis-DACH)PtCl2;1,2-diaminocyclohexane platinum(II) chloride;1,2-diaminocyclohexanedichloroplatinum(II);dichloro(1,2-diaminocyclohexane)platinum (II);dichloro(1,2-diaminocyclohexane)platinum(II);dichloro-1,2-diaminocyclohexane platinum complex;dichloro-1,2-diaminocyclohexane platinum complex, (SP-4-2(1R-trans))-isomer;dichloro-1,2-diaminocyclohexane platinum complex, (SP-4-2(1S-trans))-isomer;dichloro-1,2-diaminocyclohexane platinum complex, (SP-4-2(trans))-isomer;dichloro-1,2-diaminocyclohexane platinum complex, (SP-4-3(cis))-isomer;dichloro-1,2-diaminocyclohexaneplatinum(II);Pt 155;Pt(dach)Cl2;PtCl2(trans-dach)

Chemical Property of trans-Bis(methylammine)dichloroplatinum(II)

Chemical Property:

• Vapor Pressure: 0.46mmHg at 25°C
• Melting Point: 280 °C (dec.)(lit.)
• Boiling Point: 193.6 °C at 760 mmHg
• Flash Point: 75 °C
• PSA: 24.06000
• LogP: 2.43950
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 379.018198
• Heavy Atom Count: 11
• Complexity: 62.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dichloro(1,2-diaminocyclohexane)platinum(II) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(C(C1)N)N.[Cl-].[Cl-].[Pt+2]

Technology Process of trans-Bis(methylammine)dichloroplatinum(II)

There total 11 articles about trans-Bis(methylammine)dichloroplatinum(II) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

potassium tetrachloroplatinate + (1R,2R)-1,2-diaminocyclohexane (20439-47-8) → {(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) (38780-40-4,52691-24-4,61848-70-2,61848-66-6,61848-62-2)

Guidance literature:

In water; at 35 ℃; for 25h; Temperature; Microwave irradiation;

Reference yield: 96.0%

potassium tetrachloroplatinate(II) (10025-99-7) + (1R,2R)-1,2-diaminocyclohexane (20439-47-8) → {(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) (38780-40-4,52691-24-4,61848-70-2,61848-66-6,61848-62-2)

Guidance literature:

In water; for 4h;

DOI:10.1016/j.ica.2017.05.067

Reference yield: 82.0%

potassium tetrachloroplatinate(II) (10025-99-7) + rac-diaminocyclohexane (694-83-7) → {(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) (38780-40-4,52691-24-4,61848-70-2,61848-66-6,61848-62-2)

Guidance literature:

In hydrogenchloride; reaction mixture was held at 55°C for 72 h, then at 7°C for 10 h in absence of light and oxygen;; filtered, washed with water, dried under vacuum;;

DOI:10.1016/S0020-1693(00)81554-6

upstream raw materials:

potassium tetrachloroplatinate(II)

rac-diaminocyclohexane

Pt(IV)Cl₄(meso-1,2-cyclohexanediamine)

trans-1,2-Diaminocyclohexane

Downstream raw materials:

cis-dinitrato(1,2-diaminocyclohexane)platinum(II)

(dach)Pt(SO₄)

cis-sulfato-1,2-diaminocyclohexane-platinum(II)

(transcyclohexane-1,2-diamine)phthalate platinum(II)

Refernces

• 1、 Barbanente, Alessandra,Intini, Francesco P.,Margiotta, Nicola,Natile, Giovanni,Pacifico, Concetta. "One-Pot Synthesis of New Organometallic Compounds with Platinum-Carbon Bond". . . Retrieved 2020/02/04.
• 2、 Konovalov, Bata,?ivkovi?, Marija D.,Milovanovi?, Jelena Z.,Djordjevi?, Dragana B.,Arsenijevi?, Aleksandar N.,Vasi?, Ivana R.,Janji?, Goran V.,Franich, Andjela,Manojlovi?, Dragan,Skrivanj, Sandra,Milovanovi?, Marija Z.,Djuran, Milo? I.,Rajkovi?, Sne?ana. "Synthesis, cytotoxic activity and DNA interaction studies of new dinuclear platinum(ii) complexes with an aromatic 1,5-naphthyridine bridging ligand: DNA binding mode of polynuclear platinum(ii) complexes in relation to the complex structure". . p. 15091 - 15102. Retrieved 2018/11/10.