Chemical Property of Manumycin A
Chemical Property:
- Appearance/Colour:Yellow powder
- Vapor Pressure:8.81E-35mmHg at 25°C
- Boiling Point:863.6 °C at 760 mmHg
- PKA:3.80±0.30(Predicted)
- Flash Point:476.1 °C
- PSA：145.33000
- Density:1.26 g/cm3
- LogP:4.48570
- Storage Temp.:2-8°C
- Solubility.:Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 5 mg/ml) or in DMF (up to 20 mg/ml)
- XLogP3:4.1
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:12
- Exact Mass:550.26790156
- Heavy Atom Count:40
- Complexity:1260
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Manumycin A *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC(=O)NC3=C(CCC3=O)O)O
- Isomeric SMILES:CCCC[C@@H](C)/C=C(\C)/C=C(\C)/C(=O)NC1=C[C@]([C@H]2[C@@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O
-
Description
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 μM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant antitumor activity against Ki-ras-activated solid tumors in mice at a dose of 6.3 mg/kg. Manymycin A inhibits IκB kinase (IKK), independent of FTase inhibition, in an number of cells types with effective concentrations of 2-10 μM. In ApoE-deficient mice, Manumycin A treatment for 22 weeks at 5 mg/kg reduced aortic fatty streak lesion size to 43% of vehicle-treated animals, indicating FTase inhibition as a potential target for prevention or treatment of atherosclerosis.
-
Uses
Manumycin A from Streptomyces parvulus has been used to inhibit IκB kinase (IKK)b?nuclear κ-B essential modulator (NEMO) interaction in the homogeneous time-resolved fluorescence (HTRF)-based binding assay. Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity.
