N-[(4-methylphenyl)sulfonyl]leucine

Base Information

• Chemical Name: N-[(4-methylphenyl)sulfonyl]leucine
• CAS No.: 1220-80-0
• Molecular Formula: C₁₃H₁₉NO₄S
• Molecular Weight: 285.364
• Mol file: 1220-80-0.mol

Synonyms:LeucineN-(p-tolylsulfonyl)- (6CI,7CI); Leucine, N-(p-tolylsulfonyl)-, L- (8CI);(2S)-4-Methyl-2-[[(4-methylphenyl)sulfonyl]amino]pentanoic acid;N-Tosyl-L-leucine; N-Tosylleucine; N-p-Tosyl-L-leucine; NSC 46036; Tosylleucine

Chemical Property of N-[(4-methylphenyl)sulfonyl]leucine

Chemical Property:

• Vapor Pressure: 6.87E-09mmHg at 25°C
• Boiling Point: 450.1°Cat760mmHg
• Flash Point: 226°C
• Density: 1.218g/cm³

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(4-methylphenyl)sulfonyl]leucine

There total 12 articles about N-[(4-methylphenyl)sulfonyl]leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(p-toluenesulfonyl)-α-dehydroleucine → (S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid (1220-80-0,67368-40-5,150614-61-2)

Guidance literature:

With hydrogen; In ethanol; at 40 ℃; for 24h; under 5414.51 Torr; Product distribution / selectivity;

Reference yield: 48.0%

isopropyllithium (1888-75-1) + (2S)-N-para-toluenesulfonylaziridine-2-carboxylic acid (88452-86-2) → (S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid (1220-80-0,67368-40-5,150614-61-2)

Guidance literature:

isopropyllithium; With copper(l) cyanide; In tetrahydrofuran; pentane; at -78 - 0 ℃;

(2S)-N-para-toluenesulfonylaziridine-2-carboxylic acid; In tetrahydrofuran; pentane; at -78 - 20 ℃; Further stages.;

DOI:10.1039/b605026n

Reference yield:

phenyl isocyanate (103-71-9) + p-toluenesulfonyl chloride (98-59-9) → (S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid (1220-80-0,67368-40-5,150614-61-2)

Guidance literature:

upstream raw materials:

(S)-N-tosyl-α'-isobutyl-α-furfuryl amine

(S)-Leu-OMe

p-toluenesulfonyl chloride

N-Tosyl-DL-leucin-methylester

Downstream raw materials:

methyl tosyl-L-leucyl-L-leucinate

N-methyl-N-tosyl-L-leucine

(3S)-2,5-Dimethyl-3-(N-tosylamino)-1-hexene

(3S)-anti-2,5-Dimethyl-3-(N-tosylamino)hexan-1-ol