1-(6-Methoxyquinolin-2-yl)-1-phenylethanol

Base Information

• Chemical Name: 1-(6-Methoxyquinolin-2-yl)-1-phenylethanol
• CAS No.: 6949-90-2
• Molecular Formula: C₁₈H₁₇NO₂
• Molecular Weight: 279.338
• Hs Code.: 2933499090
• NSC Number: 25437
• DSSTox Substance ID: DTXSID60868906
• Mol file: 6949-90-2.mol

Synonyms:1-(6-methoxyquinolin-2-yl)-1-phenylethanol;6949-90-2;NSC25437;DTXSID60868906;NSC-25437;1-(6-Methoxyquinolin-2-yl)-1-phenylethan-1-ol

Chemical Property of 1-(6-Methoxyquinolin-2-yl)-1-phenylethanol

Chemical Property:

• Vapor Pressure: 5.43E-09mmHg at 25°C
• Boiling Point: 452.9°C at 760 mmHg
• Flash Point: 227.7°C
• PSA: 42.35000
• Density: 1.188g/cm³
• LogP: 3.49920
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 279.125928785
• Heavy Atom Count: 21
• Complexity: 342

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)(C2=NC3=C(C=C2)C=C(C=C3)OC)O

Technology Process of 1-(6-Methoxyquinolin-2-yl)-1-phenylethanol

There total 2 articles about 1-(6-Methoxyquinolin-2-yl)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzoyl-6-methoxy-1,2-dihydro-quinoline-2-carbonitrile (6334-31-2) + methylmagnesium bromide (75-16-1) → 1-(6-methoxy-[2]quinolyl)-1-phenyl-ethanol (6949-90-2)

Guidance literature:

With 1,4-dioxane; diethyl ether;

DOI:10.1021/ja01585a043

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + 1-benzoyl-6-methoxy-1,2-dihydro-quinoline-2-carbonitrile (6334-31-2) → 1-(6-methoxy-[2]quinolyl)-1-phenyl-ethanol (6949-90-2)

Guidance literature:

DOI:10.1021/ja01585a043

Reference yield:

1-(6-methoxy-[2]quinolyl)-1-phenyl-ethanol (6949-90-2) → 2-[1-(2-dimethylamino-ethoxy)-1-phenyl-ethyl]-6-methoxy-quinoline (102557-86-8)

Guidance literature:

With potassium; toluene; Beim anschliessenden Erhitzen mit <2-Chlor-aethyl>-dimethyl-amin;

DOI:10.1021/jo01097a005

upstream raw materials:

1-benzoyl-6-methoxy-1,2-dihydro-quinoline-2-carbonitrile

methylmagnesium bromide

1,4-dioxane

Downstream raw materials:

2-[1-(2-dimethylamino-ethoxy)-1-phenyl-ethyl]-6-methoxy-quinoline

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