Pyrazinecarboxamide, N-(piperidinomethyl)-

Base Information

Chemical Name:Pyrazinecarboxamide, N-(piperidinomethyl)-
CAS No.:1020-20-8
Molecular Formula:C₁₁H₁₆N₄O
Molecular Weight:220.274
Hs Code.:
DSSTox Substance ID:DTXSID00144519
Wikidata:Q83008762
ChEMBL ID:CHEMBL1305625
Mol file:1020-20-8.mol

Synonyms:Pyrazinecarboxamide, N-(piperidinomethyl)-;1020-20-8;n-(piperidin-1-ylmethyl)pyrazine-2-carboxamide;MLS000054105;N-(1-piperidinylmethyl)-2-pyrazinecarboxamide;SMR000061508;B 2300;N-(Piperidinomethyl)pyrazinecarboxamide;BRN 0883752;Oprea1_520037;Oprea1_633054;cid_120526;N-(piperidinomethyl)pyrazinamide;CHEMBL1305625;BDBM89606;DTXSID00144519;HMS2161P23;HMS3314H08;STL487202;AKOS000808787;AF-399/40826438;Z56842355

Suppliers and Price of Pyrazinecarboxamide, N-(piperidinomethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of Pyrazinecarboxamide, N-(piperidinomethyl)-

Chemical Property:

Vapor Pressure:8.25E-08mmHg at 25°C
Boiling Point:436.2°C at 760 mmHg
Flash Point:217.6°C
PSA：58.12000
Density:1.16g/cm³
LogP:0.97860
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:220.13241115
Heavy Atom Count:16
Complexity:228

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)CNC(=O)C2=NC=CN=C2

Technology Process of Pyrazinecarboxamide, N-(piperidinomethyl)-

There total 4 articles about Pyrazinecarboxamide, N-(piperidinomethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

: 110-89-4
piperidine

: N-(bromomethyl)pyrazine-2-carboxamide

: 1020-20-8
N-(piperidin-1-ylmethyl)pyrazine-2-carboxamide

Guidance literature:: In toluene; for 12h; Reflux;
DOI:10.1080/14756366.2017.1367774

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 1020-20-8
N-(piperidin-1-ylmethyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 8 h / Reflux

2: toluene / 8 h / Reflux

3: toluene / 12 h / Reflux

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1080/14756366.2017.1367774

Reference yield:

: 19847-10-0
pyrazinoyl chloride

: 1020-20-8
N-(piperidin-1-ylmethyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 8 h / Reflux

2: toluene / 12 h / Reflux

In toluene;
DOI:10.1080/14756366.2017.1367774