1-Boc-2-Methylazetidine-2-Methanol

Base Information

• Chemical Name: 1-Boc-2-Methylazetidine-2-Methanol
• CAS No.: 850789-22-9
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.266
• Hs Code.: 2933998090
• Mol file: 850789-22-9.mol

Synonyms:1-(tert-butoxycarbonyl)-2-(hydroxymethyl)-2-methylazetidine;1-Boc-2-(hydroxymethyl)-2-methyl-azetidine;2-Hydroxymethyl-2-methyl-azetidine-1-carboxylic acid tert-butyl ester;tert-Butyl 2-(hydroxymethyl)-2-methylazetidine-1-carboxylate;

Chemical Property of 1-Boc-2-Methylazetidine-2-Methanol

Chemical Property:

• PSA: 49.77000
• LogP: 1.31610

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl2-(hydroxymethyl)-2-methylazetidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-2-Methylazetidine-2-Methanol

There total 3 articles about 1-Boc-2-Methylazetidine-2-Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-methyl-azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-isopropyl ester (850789-21-8) → 1-(tert-butoxycarbonyl)-2-(hydroxymethyl)-2-methylazetidine (850789-22-9)

Guidance literature:

With lithium borohydride; In methanol; diethyl ether;

DOI:10.1016/j.bmcl.2005.01.058

Reference yield:

1-(tert-butoxycarbonyl)azetidine-2-carboxylic acid (159749-28-7) → 1-(tert-butoxycarbonyl)-2-(hydroxymethyl)-2-methylazetidine (850789-22-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: EDC; DMAP / CH₂Cl₂

2.1: LDA / tetrahydrofuran

2.2: tetrahydrofuran

3.1: 76 percent / LiBH₄ / methanol; diethyl ether

With dmap; lithium borohydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

DOI:10.1016/j.bmcl.2005.01.058

Reference yield:

azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-isopropyl ester → 1-(tert-butoxycarbonyl)-2-(hydroxymethyl)-2-methylazetidine (850789-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran

1.2: tetrahydrofuran

2.1: 76 percent / LiBH₄ / methanol; diethyl ether

With lithium borohydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1016/j.bmcl.2005.01.058

upstream raw materials:

2-methyl-azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-isopropyl ester

1-(tert-butoxycarbonyl)azetidine-2-carboxylic acid

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