1-[1-(4-Bromophenyl)cyclohexyl]piperidine

Base Information

Chemical Name:1-[1-(4-Bromophenyl)cyclohexyl]piperidine
CAS No.:2201-33-4
Molecular Formula:C17H24 Br N
Molecular Weight:322.288
Hs Code.:
DSSTox Substance ID:DTXSID001343233

Synonyms:1-[1-(4-bromophenyl)cyclohexyl]piperidine;DTXSID001343233;2201-33-4

Suppliers and Price of 1-[1-(4-Bromophenyl)cyclohexyl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 1-[1-(4-Bromophenyl)cyclohexyl]piperidine

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:321.10921
Heavy Atom Count:19
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)(C2=CC=C(C=C2)Br)N3CCCCC3

Technology Process of 1-[1-(4-Bromophenyl)cyclohexyl]piperidine

There total 1 articles about 1-[1-(4-Bromophenyl)cyclohexyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3867-15-0
1-piperidinocyclohexylcarbonitrile

: 106-37-6
1.4-dibromobenzene

: 2201-33-4
4-Bromophencyclidine

: 76916-13-7
1,1'-(1,4-Phenylenedicyclohexylidene)bis

Guidance literature:: With magnesium; Yield given. Multistep reaction; 1.) benzene, ether, 2.) reflux, 4 h;
DOI:10.1021/jo00323a014

Reference yield: 71.0%

: 2201-33-4
4-Bromophencyclidine

: 544-92-3
copper(I) cyanide

: 76916-14-8
4-cyanophencyclidine

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 72h;
DOI:10.1021/jo00323a014

Reference yield:

: 2201-33-4
4-Bromophencyclidine

: 76916-18-2
4-(2-Aminoethyl)phencyclidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) butyllithium, 2.) iodine / 1.) THF, -78 deg C, 2.)

2: 46 percent / triethylamine, tri-o-tolylphosphine / palladium acetate / acetonitrile / 100 °C

3: 49 percent / H₂ / 5percent Pd/C / ethanol / 72 h / 2327.2 Torr

4: 91 percent / 85percent hydrazine hydrate / methanol / Heating; reaction time: several hours

With n-butyllithium; hydrogen; iodine; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; palladium diacetate; In methanol; ethanol; acetonitrile;
DOI:10.1021/jo00326a033