3-Quinolinecarboxylic acid, 1-(3,4-difluorophenyl)-7-[(3R)-4-[(1,1-dimethylethoxy)carbonyl]-3-methyl -1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 1-(3,4-difluorophenyl)-7-[(3R)-4-[(1,1-dimethylethoxy)carbonyl]-3-methyl -1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-
• CAS No.: 850999-95-0
• Molecular Formula: C26H25F4N3O5
• Molecular Weight: 535.495
• Mol file: 850999-95-0.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 1-(3,4-difluorophenyl)-7-[(3R)-4-[(1,1-dimethylethoxy)carbonyl]-3-methyl -1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-(3,4-difluorophenyl)-7-[(3R)-4-[(1,1-dimethylethoxy)carbonyl]-3-methyl -1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-

There total 5 articles about 3-Quinolinecarboxylic acid, 1-(3,4-difluorophenyl)-7-[(3R)-4-[(1,1-dimethylethoxy)carbonyl]-3-methyl -1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

6,7,8-trifluoro-1-(3,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (106809-29-4) + (R)-tert-butyl 2-methylpiperazine-1-carboxylate (170033-47-3) → 7-((R)-4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)-6,8-difluoro-1-(3,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (850999-95-0)

Guidance literature:

With 4-methyl-morpholine; In dimethyl sulfoxide; at 120 ℃; for 24h;

DOI:10.1016/j.bmc.2005.01.032

Reference yield:

ethyl 6,7,8-trifluoro-1-(3,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate (106809-31-8) → 7-((R)-4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)-6,8-difluoro-1-(3,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (850999-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87.5 percent / acetic acid; HCl / 4 h / 100 °C

2: 96.1 percent / N-methylmorpholine / dimethylsulfoxide / 24 h / 120 °C

With 4-methyl-morpholine; hydrogenchloride; acetic acid; In dimethyl sulfoxide;

DOI:10.1016/j.bmc.2005.01.032

Reference yield:

(Z)-3-(3,4-Difluoro-phenylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester (106809-30-7) → 7-((R)-4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)-6,8-difluoro-1-(3,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (850999-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 7.96 g / K₂CO₃ / dimethylformamide / 10 h / 110 °C

2: 87.5 percent / acetic acid; HCl / 4 h / 100 °C

3: 96.1 percent / N-methylmorpholine / dimethylsulfoxide / 24 h / 120 °C

With 4-methyl-morpholine; hydrogenchloride; potassium carbonate; acetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.01.032

upstream raw materials:

6,7,8-trifluoro-1-(3,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

(R)-tert-butyl 2-methylpiperazine-1-carboxylate

ethyl 6,7,8-trifluoro-1-(3,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate

(Z)-3-(3,4-Difluoro-phenylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester