Technology Process of Benzeneacetic acid,
(3S,6E)-3-hydroxy-3,7,11-trimethyl-6,10-dodecadienyl ester
There total 4 articles about Benzeneacetic acid,
(3S,6E)-3-hydroxy-3,7,11-trimethyl-6,10-dodecadienyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,4,6-trimethyl-pyridine;
In
dichloromethane;
at -78 ℃;
for 5h;
DOI:10.1021/ol050295r
- Guidance literature:
-
Multi-step reaction with 3 steps
1: L-(+)-diisopropyl tartrate; Ti(O-i-Pr)4; TBHP / 4 Angstroem molecular sieves / CH2Cl2 / 2 h / -50 - -45 °C
2: 98 percent / Red-Al(R) / toluene / 3 h / 20 °C
3: 98 percent / 2,4,6-collidine / CH2Cl2 / 5 h / -78 °C
With
2,4,6-trimethyl-pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride;
4 A molecular sieve;
In
dichloromethane; toluene;
1: Sharpless-Katsuki epoxidation;
DOI:10.1021/ol050295r
- Guidance literature:
-
Farnesol;
With
tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; 4 A molecular sieve;
titanium(IV) isopropylate;
In
dichloromethane;
at -50 - -45 ℃;
for 2h;
With
sodium bis(2-methoxyethoxy)aluminium dihydride;
In
toluene;
at 0 - 20 ℃;
for 3h;
phenylacetyl chloride;
With
2,4,6-trimethyl-pyridine;
In
dichloromethane;
at -78 ℃;
for 5h;
Title compound not separated from byproducts;
DOI:10.1016/j.bmc.2005.04.029
