Indeno[2,1-e]indazol-7(3H)-one, 6-bromo-8,9,9a,10-tetrahydro-9a-(phenylmethyl)-

Base Information

Chemical Name:Indeno[2,1-e]indazol-7(3H)-one, 6-bromo-8,9,9a,10-tetrahydro-9a-(phenylmethyl)-
CAS No.:851107-80-7
Molecular Formula:C21H17BrN2O
Molecular Weight:393.283
Hs Code.:

Synonyms:

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Chemical Property of Indeno[2,1-e]indazol-7(3H)-one, 6-bromo-8,9,9a,10-tetrahydro-9a-(phenylmethyl)-

Chemical Property:

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Technology Process of Indeno[2,1-e]indazol-7(3H)-one, 6-bromo-8,9,9a,10-tetrahydro-9a-(phenylmethyl)-

There total 9 articles about Indeno[2,1-e]indazol-7(3H)-one, 6-bromo-8,9,9a,10-tetrahydro-9a-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 429682-70-2
N-(4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

: 851107-80-7
9a-benzyl-6-bromo-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 74 percent / NaOMe / ethanol; methanol / 6 h / 20 °C

2.1: 77 percent / H₂ / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure

3.1: sodium methoxide / methanol / 19 h / 20 °C

4.1: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C

5.1: 100 percent / NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

6.1: 75 percent / sodium methoxide / ethanol; methanol / 6.5 h / 80 °C

7.1: nitrosium tetrafluoroborate / CH₂Cl₂ / 1 h / -35 - 4 °C

7.2: 35 percent / potassium acetate; dibenzo-18-crown-6 / CH₂Cl₂ / 1 h / -35 - 20 °C

With pyrrolidine; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; nitrosonium tetrafluoroborate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm060516e

Reference yield:

: 429682-68-8
N-(4-bromo-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

: 851107-80-7
9a-benzyl-6-bromo-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 72 percent / dichlorobis(triphenylphosphine)-palladium(II); triphenylphosphine; lithium chloride / dimethylformamide / 6 h / 100 °C

2.1: 74 percent / NaOMe / ethanol; methanol / 6 h / 20 °C

3.1: 77 percent / H₂ / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure

4.1: sodium methoxide / methanol / 19 h / 20 °C

5.1: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C

6.1: 100 percent / NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

7.1: 75 percent / sodium methoxide / ethanol; methanol / 6.5 h / 80 °C

8.1: nitrosium tetrafluoroborate / CH₂Cl₂ / 1 h / -35 - 4 °C

8.2: 35 percent / potassium acetate; dibenzo-18-crown-6 / CH₂Cl₂ / 1 h / -35 - 20 °C

With pyrrolidine; bis-triphenylphosphine-palladium(II) chloride; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; nitrosonium tetrafluoroborate; acetic acid; triphenylphosphine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.1: Stille coupling;
DOI:10.1021/jm060516e

Reference yield:

: 851107-75-0
N-(2-benzylidene-4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

: 851107-80-7
9a-benzyl-6-bromo-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 77 percent / H₂ / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure

2.1: sodium methoxide / methanol / 19 h / 20 °C

3.1: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C

4.1: 100 percent / NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

5.1: 75 percent / sodium methoxide / ethanol; methanol / 6.5 h / 80 °C

6.1: nitrosium tetrafluoroborate / CH₂Cl₂ / 1 h / -35 - 4 °C

6.2: 35 percent / potassium acetate; dibenzo-18-crown-6 / CH₂Cl₂ / 1 h / -35 - 20 °C

With pyrrolidine; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; nitrosonium tetrafluoroborate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm060516e