N-(4-butoxyphenyl)-2-chloroacetamide

Base Information

• Chemical Name: N-(4-butoxyphenyl)-2-chloroacetamide
• CAS No.: 41240-84-0
• Molecular Formula: C12H16ClNO2
• Molecular Weight: 241.7139
• Hs Code.: 2924299090
• NSC Number: 165620
• DSSTox Substance ID: DTXSID10304400
• Wikidata: Q82050292
• Mol file: 41240-84-0.mol

Synonyms:N-(4-butoxyphenyl)-2-chloroacetamide;41240-84-0;NSC165620;N-(4-butoxy-phenyl)-2-chloro-acetamide;SCHEMBL7288606;DTXSID10304400;MFCD02335307;STK665897;AKOS000369994;NSC-165620;LS-06259;CS-0116866

Chemical Property of N-(4-butoxyphenyl)-2-chloroacetamide

Chemical Property:

• Vapor Pressure: 7.64E-07mmHg at 25°C
• Boiling Point: 407.3°Cat760mmHg
• Flash Point: 200.1°C
• PSA: 38.33000
• Density: 1.165g/cm³
• LogP: 3.11580
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 241.0869564
• Heavy Atom Count: 16
• Complexity: 203

Purity/Quality:

99%min ^*data from raw suppliers

N-(4-Butoxyphenyl)-2-chloroacetamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCOC1=CC=C(C=C1)NC(=O)CCl

Technology Process of N-(4-butoxyphenyl)-2-chloroacetamide

There total 2 articles about N-(4-butoxyphenyl)-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

para-butoxyaniline (4344-55-2) + chloroacetyl chloride (79-04-9) → N-(4-butoxy-phenyl)-2-chloro-acetamide (41240-84-0)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; for 0.5h;

DOI:10.1007/BF00758665

Reference yield:

→ N-(4-butoxy-phenyl)-2-chloro-acetamide (41240-84-0)

Guidance literature:

4-Butyloxy-anilin, ClCH2-COCl, Eg., 5grad;

Reference yield:

N-(4-butoxy-phenyl)-2-chloro-acetamide (41240-84-0) → N-(4-Butoxy-phenyl)-2-piperidin-1-yl-acetamide; compound with oxalic acid (81112-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 2 h / Heating

2: diethyl ether

In diethyl ether; acetone;

DOI:10.1007/BF00758665

upstream raw materials:

para-butoxyaniline

chloroacetyl chloride

Downstream raw materials:

N-(4-butoxy-phenyl)-2-morpholin-4-yl-acetamide

N-(4-butyloxy-phenyl)-2-piperidin-1-yl-acetamide

N-(4-Butoxy-phenyl)-2-piperidin-1-yl-acetamide; compound with oxalic acid

Refernces

• 1、 -. "BENZODIOXANYL-HYDROXYETHYLENEAMINO-PIPERIDINYL ACETANILIDES, KETONES, ESTERS AND CARBAMATES WHICH EFFECT IMMUNITY AND CALCIUM ENTRY AND BETA-BLOCKADE". . . Retrieved 2008/06/13.
• 2、 Virsis, I. E.,Silaraya, D. A.,Grinberga, B. A.,Prikulis, A. A.,Gerbashevska, I. D.,Orenish, M. E.. "SYNTHESIS AND STUDY OF &α-PIPERIDINOACETANILIDES AS MONOAMINE OXIDASE INHIBITORS". . p. 849 - 853. Retrieved 2007/10/02.