5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[[2 -(2-hydroxypropoxy)-3-methyl-4-pyridinyl]methyl]-

Base Information

Chemical Name:5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[[2 -(2-hydroxypropoxy)-3-methyl-4-pyridinyl]methyl]-
CAS No.:851314-24-4
Molecular Formula:C36H40ClF2N3O4
Molecular Weight:652.181
Hs Code.:

5-Azaspiro[2.5]oct-7-ene-7-carboxamide,
8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[[2
-(2-hydroxypropoxy)-3-methyl-4-pyridinyl]methyl]-

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Chemical Property of 5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[[2 -(2-hydroxypropoxy)-3-methyl-4-pyridinyl]methyl]-

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Technology Process of 5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[[2 -(2-hydroxypropoxy)-3-methyl-4-pyridinyl]methyl]-

There total 13 articles about 5-Azaspiro[2.5]oct-7-ene-7-carboxamide, 8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[[2 -(2-hydroxypropoxy)-3-methyl-4-pyridinyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₇H₆₂ClF₂N₃O₆Si

: 851314-24-4
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-7-carboxylic acid cyclopropyl-[2-(2-hydroxypropoxy)-3-methylpyridin-4-ylmethyl]amide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 790696-97-8
(2-chloro-3-methyl-pyridin-4-ylmethyl)-cyclopropyl-amine

: 851314-24-4
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-7-carboxylic acid cyclopropyl-[2-(2-hydroxypropoxy)-3-methylpyridin-4-ylmethyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane / 12 h / 115 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dmap; benzotriazol-1-ol / dichloromethane / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1.5 h / 0 - 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dmap; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane;

Reference yield:

: 143306-64-3
tert-butyl 8-oxo-5-azaspiro[2.5]octane-5-carboxylate

: 851314-24-4
8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-7-carboxylic acid cyclopropyl-[2-(2-hydroxypropoxy)-3-methylpyridin-4-ylmethyl]amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 3 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 18 h / 20 - 50 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 0.33 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C

5.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 2 h / 20 - 80 °C

6.1: sodium hydroxide; water / 1.5 h / 80 °C

6.2: 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dmap; benzotriazol-1-ol / dichloromethane / 20 °C

8.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; tributylphosphine; tetrabutyl ammonium fluoride; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; 1,1'-azodicarbonyl-dipiperidine; dmap; benzotriazol-1-ol; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; toluene; 5.1: Mitsunobu reaction;