1-Benzyl-5,5-Difluoro-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester

Base Information

Chemical Name:1-Benzyl-5,5-Difluoro-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester
CAS No.:851314-56-2
Molecular Formula:C15H17F2NO3
Molecular Weight:297.302
Hs Code.:2933399090
Mol file:851314-56-2.mol

Synonyms:ethyl 1-benzyl-5,5-difluoro-4-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylate;Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate;

Suppliers and Price of 1-Benzyl-5,5-Difluoro-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl1-benzyl-5,5-difluoro-4-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylate 95+%
5g
$ 1116.00

Crysdot
Ethyl1-benzyl-5,5-difluoro-4-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylate 95+%
1g
$ 371.00

Total 2 raw suppliers

Chemical Property of 1-Benzyl-5,5-Difluoro-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester

Chemical Property:

PSA：49.77000
LogP:2.45060

Purity/Quality:

99% ^*data from raw suppliers

Ethyl1-benzyl-5,5-difluoro-4-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-5,5-Difluoro-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester

There total 4 articles about 1-Benzyl-5,5-Difluoro-4-Oxo-Piperidine-3-Carboxylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: C₁₆H₂₁F₂NO₄

: 851314-56-2
ethyl 5,5-difluoro-4-hydroxy-1-(phenylmethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 18h;
DOI:10.1016/j.bmcl.2009.09.104

Reference yield: 38.0%

: 851314-55-1
ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate

: 851314-56-2
ethyl 5,5-difluoro-4-hydroxy-1-(phenylmethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2011.08.094

Reference yield:

: 851314-54-0
ethyl N-(1H-1,2,3-benzotriazol-1-ylmethyl)-N-(phenylmethyl)-beta-alaninate

: 851314-56-2
ethyl 5,5-difluoro-4-hydroxy-1-(phenylmethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane; zinc / tetrahydrofuran / 0.17 h / 20 °C

1.2: 18 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.17 h / -78 - 20 °C / Molecular sieve; Cooling with acetone-dry ice

With chloro-trimethyl-silane; zinc; lithium diisopropyl amide; In tetrahydrofuran;