Technology Process of Oxiranemethanol,
3-[3-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-3-ethenyl-4-pentenyl]-,
(2S,3S)-
There total 10 articles about Oxiranemethanol,
3-[3-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-3-ethenyl-4-pentenyl]-,
(2S,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate;
4 A molecular sieve;
In
dichloromethane;
at -25 ℃;
for 10h;
DOI:10.1055/s-2005-862388
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 84 percent / Hg(OAc)2 / 18 h / 50 °C
2: 88 percent / i-Bu3Al / CH2Cl2 / 1 h / 20 °C
3: imidazole; 4-DMAP / CH2Cl2 / 0.25 h / 20 °C
4: TMSCl; EtOH / 0.33 h / 20 °C
5: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 0.5 h / 20 °C
6: 95 percent / benzene / 1.5 h / 80 °C
7: 95 percent / i-Bu2AlH / tetrahydrofuran / 0.17 h / 20 °C
8: (+)-DIPT; (i-PrO)4Ti; TBHP / 4 Angstroem molecular sieves / CH2Cl2 / 10 h / -25 °C
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; chloro-trimethyl-silane; oxalyl dichloride; ethanol; L-(+)-diisopropyl tartrate; mercury(II) diacetate; triisobutylaluminum; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; benzene;
2: reductive Claisen rearrangement / 5: Swern oxidation / 6: Wittig reaction / 8: Katsuki-Sharpless asymmetric epoxidation;
DOI:10.1055/s-2005-862388
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 88 percent / i-Bu3Al / CH2Cl2 / 1 h / 20 °C
2: imidazole; 4-DMAP / CH2Cl2 / 0.25 h / 20 °C
3: TMSCl; EtOH / 0.33 h / 20 °C
4: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 0.5 h / 20 °C
5: 95 percent / benzene / 1.5 h / 80 °C
6: 95 percent / i-Bu2AlH / tetrahydrofuran / 0.17 h / 20 °C
7: (+)-DIPT; (i-PrO)4Ti; TBHP / 4 Angstroem molecular sieves / CH2Cl2 / 10 h / -25 °C
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; chloro-trimethyl-silane; oxalyl dichloride; ethanol; L-(+)-diisopropyl tartrate; triisobutylaluminum; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; benzene;
1: reductive Claisen rearrangement / 4: Swern oxidation / 5: Wittig reaction / 7: Katsuki-Sharpless asymmetric epoxidation;
DOI:10.1055/s-2005-862388
![6-[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-ethyl]-6-vinyl-octa-2,7-dien-1-ol](/Databaselist/images/loading.webp)
