1,9-Phenanthroline-4-carboxylic acid, 2-[(4-chlorophenyl)methyl]-7,8,9,10-tetrahydro-3-hydroxy-9-(1-methyleth yl)-

Base Information

Chemical Name:1,9-Phenanthroline-4-carboxylic acid, 2-[(4-chlorophenyl)methyl]-7,8,9,10-tetrahydro-3-hydroxy-9-(1-methyleth yl)-
CAS No.:851547-04-1
Molecular Formula:C23H23ClN2O3
Molecular Weight:410.9
Hs Code.:

Synonyms:

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Chemical Property of 1,9-Phenanthroline-4-carboxylic acid, 2-[(4-chlorophenyl)methyl]-7,8,9,10-tetrahydro-3-hydroxy-9-(1-methyleth yl)-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1,9-Phenanthroline-4-carboxylic acid, 2-[(4-chlorophenyl)methyl]-7,8,9,10-tetrahydro-3-hydroxy-9-(1-methyleth yl)-

There total 9 articles about 1,9-Phenanthroline-4-carboxylic acid, 2-[(4-chlorophenyl)methyl]-7,8,9,10-tetrahydro-3-hydroxy-9-(1-methyleth yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 851547-02-9
2-(4-Chloro-benzyl)-3-hydroxy-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

: 67-64-1
acetone

: 851547-04-1
2-(4-Chloro-benzyl)-3-hydroxy-9-isopropyl-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

Guidance literature:: With sodium cyanoborohydride; acetic acid; triethylamine; In methanol; at 25 ℃;
DOI:10.1021/jm060631p

Reference yield:

: 924633-49-8
1,2,3,4-tetrahydro-8-isoquinolineamine

: 851547-04-1
2-(4-Chloro-benzyl)-3-hydroxy-9-isopropyl-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaHCO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2: NH₂OH*HCl; Na₂SO₄; aq. HCl / CH₂Cl₂ / 55 °C

3: H₂SO₄ / 55 - 80 °C

4: 16 percent / aq. NaOH / ethanol / 2 h / Heating

5: 32 percent / NaBH₃CN; Et₃N; AcOH / methanol / 25 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydroxylamine hydrochloride; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; sodium sulfate; triethylamine; In methanol; ethanol; dichloromethane; 2: Sandmeyer reaction / 4: Pfitzinger reaction;
DOI:10.1021/jm060631p

Reference yield:

: 76258-55-4
2-acetyl-1,2,3,4-tetrahydro-8-isoquinolineamine

: 851547-04-1
2-(4-Chloro-benzyl)-3-hydroxy-9-isopropyl-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NH₂OH*HCl; Na₂SO₄; aq. HCl / CH₂Cl₂ / 55 °C

2: H₂SO₄ / 55 - 80 °C

3: 16 percent / aq. NaOH / ethanol / 2 h / Heating

4: 32 percent / NaBH₃CN; Et₃N; AcOH / methanol / 25 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydroxylamine hydrochloride; sodium cyanoborohydride; acetic acid; sodium sulfate; triethylamine; In methanol; ethanol; dichloromethane; 1: Sandmeyer reaction / 3: Pfitzinger reaction;
DOI:10.1021/jm060631p