benzyloxycarbonylalanyl-alanyl phenylalanine chloromethyl ketone

Base Information

Chemical Name:benzyloxycarbonylalanyl-alanyl phenylalanine chloromethyl ketone
CAS No.:86832-16-8
Molecular Formula:C₂₄H₂₈ClN₃O₅
Molecular Weight:473.956
Hs Code.:

Synonyms:{(S)-1-[(S)-1-((S)-1-Benzyl-3-chloro-2-oxo-propylcarbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid benzyl ester;Z-AAF-CMK (Z-ALA-ALA-PHE-CMK);

Suppliers and Price of benzyloxycarbonylalanyl-alanyl phenylalanine chloromethyl ketone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of benzyloxycarbonylalanyl-alanyl phenylalanine chloromethyl ketone

Chemical Property:

Vapor Pressure:2.82E-17mmHg at 25°C
Boiling Point:659.7°Cat760mmHg
Flash Point:352.8°C
PSA：113.60000
Density:1.241g/cm³
LogP:3.51410

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benzyloxycarbonylalanyl-alanyl phenylalanine chloromethyl ketone

There total 2 articles about benzyloxycarbonylalanyl-alanyl phenylalanine chloromethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2483-51-4
N-[(benzyloxy)carbonyl]-L-alanyl-L-alanine methyl ester

: 86832-16-8
Z-Ala₂-PheCH₂Cl

Guidance literature:: Multi-step reaction with 2 steps

1: 1 N aq. NaOH, 4-(dimethylamino)-pyridine / pyridine / Ambient temperature

2: 1.) NEt₃, butyl chlorocarbonate; 2.) NEt₃ / 1.) -15 deg C, 7-8 min; 2.) THF, -10 deg C, 1 h

With dmap; sodium hydroxide; triethylamine; carbonochloridic acid, butyl ester; In pyridine;

Reference yield:

: 16012-70-7
benzyloxycarbonyl-L-alanyl-L-alanine

: 25487-25-6
PheCH₂Cl, HBr

: 86832-16-8
Z-Ala₂-PheCH₂Cl

Guidance literature:: With triethylamine; carbonochloridic acid, butyl ester; Yield given. Multistep reaction; 1.) -15 deg C, 7-8 min; 2.) THF, -10 deg C, 1 h;

Reference yield:

: 86832-16-8
Z-Ala₂-PheCH₂Cl

: 90302-95-7
Z-Ala₄-PheCH₂Cl

Guidance literature:: Multi-step reaction with 2 steps

1: 4 N HBr / acetic acid / 0.5 h / Ambient temperature

2: 1.) N-Ethylmorpholine, butyl chlorocarbonate; 2.) NEt₃ / 1.) DMF, -15 deg C, 7-8 min; 2.) THF, -10 deg C, 1 h

With N-ethylmorpholine;; hydrogen bromide; triethylamine; carbonochloridic acid, butyl ester; In acetic acid;