25487-25-6

Upstream product

• 26049-94-5 (S)-benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate 
• 15196-02-8 (S)-3-[(benzyloxycarbonyl)amino]-1-diazo-4-phenyl-2-butanone 
• 109453-49-8 (C₈H₇O₂)(NHCHCOO)(CH₂C₆H₅)(CO₂C₂H₅) 
• 1161-13-3 N-Cbz-L-Phe 

Downstream Products

• 89595-83-5 Z-Ala₃-PheCH₂Cl 
• 26049-92-3 Z-Ala-PheCH₂Cl 
• 86832-16-8 Z-Ala₂-PheCH₂Cl 
• 106815-03-6 Boc-Tyr-Leu-Phe-CH₂Cl 
• 89595-82-4 Z-Pro-PheCH₂Cl 
• 90302-96-8 Ac-Ala₃-PheCH₂Cl 
• 90303-02-9 Ala-PheCH₂Cl, HBr 
• 90302-99-1 Ac-Ala₂-Pro-PheCH₂Cl 
• 90303-01-8 Pro-PheCH₂Cl, HBr 
• 90302-98-0 Ac-Ala₂-Phe-PheCH₂Cl 
• 90303-00-7 Phe-PheCH₂Cl, HBr 
• 90302-94-6 Z-Phe-PheCH₂Cl 

Relevant academic research and scientific papers

ACYLAMINOALKANOYL URETHANES OR THIOURETHANES

Compounds of the formula STR1 wherein Z is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analges

CERTAIN ACYCLIC, ALICYCLIC, AROMATIC OR HETEROCYCLIC DERIVATIVES OF 3-BENZOYLAMINO-2-OXO- BUTYL-AMINO-CARBONYL-OXY-3-PROPANOIC ACIDS, ESTERS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR ENKEPHALINASE INHIBITING PROPERTIES

Compounds of the formula STR1 wherein Y is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of R 1 may also be useful as analgesics due to their enkepahlinase inhibition activity.

α-Amino Ketones - A Contribution to the Synthesis of Optically Active Derivatives of Amino Acids and Peptides

The synthesis of N-Z-protected methyl ketones from amino acids via the chloromethyl ketones and dehalogenation of the latter with zinc in glacial acetic acid is described.Deprotection of the methyl ketones results in the formation of hydrohalogenides of the α-aminoalkyl methyl ketones further converted to N-acylated peptide ketones as analogs of peptide hormones or as competitively acting substrate analogs of proteolytic enzymes.Aminoacetone is conveniently prepared as well as methyl-pyrrolidyl ketone and methyl-piperidyl ketone.

HYDROXY SUBSTITUTED UREIDO AMINO AND IMINO ACIDS

Compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase

ACYLAMINO OXO OR HYDROXY SUBSTITUTED ALKYLAMINO THIAZINES AND THIAZEPINES

Compounds of the formula STR1 and X is an oxo substituted thiazine or thiazepine are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.

HYDROXY SUBSTITUTED PEPTIDE COMPOUNDS

Hydroxy substituted peptide compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

SUBSTITUTED PEPTIDE COMPOUNDS

Substituted peptide compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

LACTAM CONTAINING COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE

Compounds of the formula STR1 are disclosed wherein R is STR2 The compounds possess hypotensive activity.