2,2'-Bipyridine-4-carboxylic acid

Base Information

• Chemical Name: 2,2'-Bipyridine-4-carboxylic acid
• CAS No.: 1748-89-6
• Molecular Formula: C11H8N2O2
• Molecular Weight: 200.197
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50433122
• Nikkaji Number: J1.098.396G
• Pharos Ligand ID: 488H6GUAWFC7
• ChEMBL ID: CHEMBL3621852
• Mol file: 1748-89-6.mol

Synonyms:1748-89-6;[2,2'-Bipyridine]-4-carboxylic acid;2,2'-BIPYRIDINE-4-CARBOXYLIC ACID;2-pyridin-2-ylpyridine-4-carboxylic Acid;2,2/'-Bipyridine-4-carboxylic acid;CHEMBL3621852;2,2-bipyridyl-4-carboxylic;4-Carboxy-2,2'-bipyridine;SCHEMBL913277;YSCH0069;DTXSID50433122;BAA74889;BDBM50498673;MFCD09414714;[2,2'-Bipyridine]-4-carboxylicacid;AKOS005266518;CS-W018446;TS-02831;2,2'-bipyridine-4-carboxylic acid, AldrichCPR;J-400149

Chemical Property of 2,2'-Bipyridine-4-carboxylic acid

Chemical Property:

• Boiling Point: 502.5°Cat760mmHg
• Flash Point: 257.7°C
• PSA: 63.08000
• Density: 1.302g/cm³
• LogP: 1.84180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 200.058577502
• Heavy Atom Count: 15
• Complexity: 233

Purity/Quality:

97% ^*data from raw suppliers

2,2'-Bipyridine-4-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=NC=CC(=C2)C(=O)O

Technology Process of 2,2'-Bipyridine-4-carboxylic acid

There total 3 articles about 2,2'-Bipyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-carbomethoxy-2,2′-bipyridine (98820-73-6) → 2,2'-bipyridine-4-carboxylic acid (1748-89-6)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1021/jo9814795

Reference yield:

methyl 2-chloroisonicotinate (58481-11-1) → 2,2'-bipyridine-4-carboxylic acid (1748-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / (PPh₃)2PdCl₂ / m-xylene / 12 h / 135 °C

2: 89 percent / aq. NaOH / methanol / 20 °C

With sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; m-xylene; 1: Condensation / 2: Hydrolysis;

DOI:10.1021/jo9814795

Reference yield:

2-trimethylstannylpyridine (13737-05-8) → 2,2'-bipyridine-4-carboxylic acid (1748-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / (PPh₃)2PdCl₂ / m-xylene / 12 h / 135 °C

2: 89 percent / aq. NaOH / methanol / 20 °C

With sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; m-xylene; 1: Condensation / 2: Hydrolysis;

DOI:10.1021/jo9814795

upstream raw materials:

4-carbomethoxy-2,2′-bipyridine

methyl 2-chloroisonicotinate

2-trimethylstannylpyridine

Downstream raw materials:

2,2′-bipyridine-4-carboxylic acid chloride

C₂₀H₁₉N₃O