58481-11-1

Basic information

• Product Name: METHYL 2-CHLOROISONICOTINATE
• Synonyms: 2-CHLORO-ISONICOTINIC ACID METHYL ESTER;BUTTPARK 91\04-05;METHYL 2-CHLOROISONICOTINATE;METHYL 2-CHLOROPYRIDINE-4-CARBOXYLATE;METHYL 2-CHLORO-4-PYRIDINECARBOXYLATE;Methyl 2-chloroisonicotinate ,98%;4-Pyridinecarboxylic acid, 2-chloro-, methyl ester;Methyl 2-chloroisonicotin...
• CAS NO: 58481-11-1
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• Product Categories: blocks;Carboxes;Pyridines;Esters;Pyridine;Picolinic acid series;alkyl chloride|carboxylic ester
• Mol File: 58481-11-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 32-36 °C
• Boiling Point: 70°C/0.1mmHg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.294 g/cm³
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: 2-8°C
• PKA: -1.15±0.10(Predicted)
• CAS DataBase Reference: METHYL 2-CHLOROISONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-CHLOROISONICOTINATE(58481-11-1)
• EPA Substance Registry System: METHYL 2-CHLOROISONICOTINATE(58481-11-1)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 58481-11-1(Hazardous Substances Data)

Usage

Chemical Properties

White to light brown solid

InChI:InChI=1/C7H6ClNO2/c1-11-7(10)5-2-3-9-6(8)4-5/h2-4H,1H3

Upstream product

• 3783-38-8 methyl isonicotinate N-oxide 
• 6313-54-8 2-chloroisonicotinic acid, 
• 34472-65-6 (trimethylsilyl)diazomethane 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 65287-34-5 2-chloropyridine-4-carbonyl chloride 

Downstream Products

• 119836-24-7 methyl 3-(2-chloropyridin-4-yl)-3-oxopropanoate 
• 42729-22-6 2-(3-trifluoromethylphenyl)amine-4-pyridinecarboxylic acid 
• 85726-32-5 methyl 2-[[3-(trifluoromethyl)phenyl]amino]isonicotinate 
• 85726-26-7 2-chloro-4-(N-4-chlorophenyl)pyridinecarboxyamide 
• 85726-31-4 methyl 2-((4-chlorophenyl)amino)isonicotinate 
• 85726-33-6 2-(4-Methoxy-phenylamino)-isonicotinic acid methyl ester 
• 85726-25-6 2-chloro-4-(N-3,4-dichlorophenyl)pyridinecarboxyamide 
• 85726-28-9 2-(3,4-dichlorophenyl)amine-4-pyridinecarboxylic acid 
• 85726-27-8 2-(3,4-dichlorophenyl)amine-4-(N-3,4-dichlorophenyl)pyridinecarboxyamide 
• 85726-30-3 2-(3,4-Dichloro-phenylamino)-isonicotinic acid methyl ester 
• 100704-10-7 (2-chloropyridin-4-yl)methanol 
• 118287-89-1 2-chloro-4-diethoxymethylpyridine 
• 101066-61-9 2-chloropyridine-4-carbaldehyde 
• 220340-37-4 4-hydroxymethyl-2,2'-bipyridine 

Relevant articles and documents

FLUOROINDOLE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor.(Formula I) (I)

Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives

In present study, a series of new 2-(1,3,4-oxadiazol-2-ylthio)-1- phenylethanone derivatives (6a-6x) as potential focal adhesion kinase (FAK) inhibitors were synthesized. The bioassay assays demonstrated that compound 6i showed the most potent activity, which inhibited the growth of MCF-7 and A431 cell lines with IC50 values of 140 ± 10 nM and 10 ± 1 nM, respectively. Compound 6i also exhibited significant FAK inhibitory activity (IC50 = 20 ± 1 nM). Docking simulation was performed to position compound 6i into the active site of FAK to determine the probable binding model.

METHODS FOR TREATING CHRONIC PAIN USING 3-ARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES, 3-HETEROARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using compounds of Formulas 1 and 2 wherein the variables have the meaning disclosed in the specification