(5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione

Base Information

Chemical Name:(5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione
CAS No.:852391-19-6
Molecular Formula:C₁₃H₁₂ClN₃O₂
Molecular Weight:277.71
Hs Code.:2933998090
European Community (EC) Number:813-204-7
ChEMBL ID:CHEMBL370438
Pharos Ligand ID:ZGXK7ZT3FG9F
Wikidata:Q27464898
Mol file:852391-19-6.mol

Synonyms:Necrostatin 2;852391-19-6;Necrostatin-2;(5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione;852391-19-6 (R-isomer);(5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-Imidazolidinedione;4ith;2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5R)-;CID11288934;SCHEMBL860317;CHEMBL370438;BDBM36372;CJB39119;LDN-58205;(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidin edione;2,4-Imidazolidinedione,5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-,(5R)-;AKOS030526929;CS-1511;HY-14622;MS-23945;F17945;A914816;Q27464898;(R)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione;(5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-Imidazolidinedione, 11;RCM

Suppliers and Price of (5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Necrostatin2 98+%
50mg
$ 438.00

Crysdot
Necrostatin2 98+%
10mg
$ 184.00

Crysdot
Necrostatin2 98+%
5mg
$ 121.00

Chemenu
(R)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione 95%+
50mg
$ 410.00

Cayman Chemical
Necrostatin-2 ≥98%
10mg
$ 198.00

Cayman Chemical
Necrostatin-2 ≥98%
1mg
$ 29.00

Cayman Chemical
Necrostatin-2 ≥98%
5mg
$ 106.00

ApexBio Technology
Necrostatin2
1mg
$ 103.00

ApexBio Technology
Necrostatin2
5mg
$ 273.00

ApexBio Technology
Necrostatin2
10mg
$ 414.00

Total 8 raw suppliers

Chemical Property of (5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione

Chemical Property:

PKA:8.48±0.70(Predicted)
PSA：68.69000
Density:1.450±0.06 g/cm3(Predicted)
LogP:1.49190
Solubility.:Soluble in DMSO
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:277.0618043
Heavy Atom Count:19
Complexity:403

Purity/Quality:

97% ^*data from raw suppliers

Necrostatin2 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
Isomeric SMILES:CN1C(=O)[C@H](NC1=O)CC2=CNC3=C2C=CC=C3Cl

Technology Process of (5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione

There total 3 articles about (5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[1-(7-Chloro-1H-indol-3-yl)-meth-(Z)-ylidene]-3-methyl-imidazolidine-2,4-dione

: 852391-19-6
Nec-1s

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2005.07.077

Reference yield:

: 1008-07-7
7-chloro-1H-indole-3-carboxaldehyde

: 852391-19-6
Nec-1s

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / 4 h / 110 °C

2: CoCl₂; NaBH₄ / methanol; tetrahydrofuran / 24 h / 20 °C

With piperidine; sodium tetrahydroborate; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.07.077