1H-Pyrrole, 2,5-diphenyl-1-(phenylmethyl)-

Base Information

• Chemical Name: 1H-Pyrrole, 2,5-diphenyl-1-(phenylmethyl)-
• CAS No.: 853-72-5
• Molecular Formula: C23H19N
• Molecular Weight: 309.411
• Mol file: 853-72-5.mol

Synonyms:1-benzyl-2,5-diphenylpyrrole;1-Benzyl-2,5-diphenyl-1H-pyrrole;1-Benzyl-2,5-diphenyl-pyrrol;1-benzyl-2,5-diphenyl-pyrrole;N-benzyl-2,5-diphenylpyrrole;

Chemical Property of 1H-Pyrrole, 2,5-diphenyl-1-(phenylmethyl)-

Chemical Property:

• Melting Point: 144 °C
• Boiling Point: 460.0±14.0 °C(Predicted)
• PSA: 4.93000
• Density: 1.03±0.1 g/cm3(Predicted)
• LogP: 5.87040

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole, 2,5-diphenyl-1-(phenylmethyl)-

There total 11 articles about 1H-Pyrrole, 2,5-diphenyl-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzylamine (100-46-9) + phenacylacetophenone (495-71-6) → 1-benzyl-2,5-diphenyl-1H-pyrrole (853-72-5)

Guidance literature:

With choline chloride; urea; at 80 ℃; for 24h;

DOI:10.1016/j.tetlet.2013.05.122

Reference yield: 84.0%

1-benzyl-1H-pyrrole (2051-97-0) + iodobenzene (591-50-4) → 1-benzyl-2,5-diphenyl-1H-pyrrole (853-72-5)

Guidance literature:

With silver (II) carbonate; palladium diacetate; Trimethylacetic acid; In water; at 40 ℃; for 24h; Reagent/catalyst; Temperature; regioselective reaction;

DOI:10.1021/acs.joc.5b00451

Reference yield: 61.0%

1,4-diphenyl-but-2-yne-1,4-dione (1087-09-8) + benzylamine (100-46-9) → 1-benzyl-2,5-diphenyl-1H-pyrrole (853-72-5)

Guidance literature:

With PEG-200; formic acid; palladium on activated charcoal; for 0.0166667h; microwave irradiation;

DOI:10.1016/j.tet.2003.11.087

upstream raw materials:

tetra-N-methyl-1,4-diphenyl-buta-1,3-dienediyldiamine

benzylamine

phenacylacetophenone

N-benzyl-N-(1-phenylethylidene)amine

Downstream raw materials:

1-benzyl-3-nitro-2,5-diphenyl-pyrrole

1-benzyl-3,4-dinitro-2,5-diphenyl-pyrrole

1-benzyl-2,5-diphenyl-3-acetylpyrrole

1-Benzyl-3,4-dibromo-2,5-diphenylpyrrole