2-Indanol

Base Information

• Chemical Name: 2-Indanol
• CAS No.: 4254-29-9
• Molecular Formula: C9H10O
• Molecular Weight: 134.178
• Hs Code.: 29062990
• European Community (EC) Number: 224-230-8
• NSC Number: 17485
• UNII: B77NA7SM29
• DSSTox Substance ID: DTXSID30195332
• Nikkaji Number: J113.865K
• Wikidata: Q72482736
• Mol file: 4254-29-9.mol

Synonyms:2-indanol

Chemical Property of 2-Indanol

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.012mmHg at 25°C
• Melting Point: 68-71 °C(lit.)
• Refractive Index: 1.609
• Boiling Point: 249.5 °C at 760 mmHg
• PKA: 15.17±0.20(Predicted)
• Flash Point: 87.6 °C
• PSA: 20.23000
• Density: 1.161g/cm³
• LogP: 1.14610
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: 6 g/L (20 ºC)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 134.073164938
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

98% ^*data from raw suppliers

2-Indanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22-36
• Safety Statements: 37/39-26-36/37/39-27-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Alcohols and Polyols, Other
• Canonical SMILES: C1C(CC2=CC=CC=C21)O
• Uses: 2-Indanamine metabolite.

Technology Process of 2-Indanol

There total 65 articles about 2-Indanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-indanone (615-13-4) → indan-2-ol (4254-29-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2015.12.028

Reference yield: 99.0%

2-(allyloxy)-2,3-dihydro-1H-indene → indan-2-ol (4254-29-9)

Guidance literature:

quinoline-2-carboxylic acid; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; In methanol; at 30 ℃; for 3h; Conversion of starting material;

Reference yield: 90.0%

2,3-epoxyindene (768-22-9) → indan-2-ol (4254-29-9)

Guidance literature:

With zinc(II) tetrahydroborate; silica gel; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1039/c39900001334

upstream raw materials:

trans-2-bromo-1-indanol

2-indanone

2,3-epoxyindene

1-bromo-indan-2-ol

Downstream raw materials:

5,6,7,8-tetrahydroindan-2-ol

2-iodoindane

2-bromoindane

indan-2-yl p-toluenesulphonate

Refernces

• 1、 Balsamo et al.. "-". . p. 2596. Retrieved 1974.
• 2、 Bajwa,Vivelo,Slade,Repic,Blacklock. "Selective deprotection of alkyl t-butyldimethylsilyl ethers in the presence of aryl t-butyldimethylsilyl ethers with bismuth bromide". . p. 6021 - 6024. Retrieved 2000.
• 3、 Liu, Xin,Longwitz, Lars,Spiegelberg, Brian,T?njes, Jan,Beweries, Torsten,Werner, Thomas. "Erbium-Catalyzed Regioselective Isomerization-Cobalt-Catalyzed Transfer Hydrogenation Sequence for the Synthesis of Anti-Markovnikov Alcohols from Epoxides under Mild Conditions". . p. 13659 - 13667. Retrieved 2020/11/30.
• 4、 Fischer, Logan J.,Gehrmann, Elizabeth J.,Peterson, Julie A.,Shrestha, Pradeep,Smith, Emily A.,Wijesooriya, Chamari S.,Winter, Arthur H.,Yuan, Ding. "Direct Photorelease of Alcohols from Boron-Alkylated BODIPY Photocages". supporting information. p. 5712 - 5717. Retrieved 2020/05/19.