Silane, (chloromethyl)bis(4-fluorophenyl)methyl-

Base Information

• Chemical Name: Silane, (chloromethyl)bis(4-fluorophenyl)methyl-
• CAS No.: 85491-26-5
• Molecular Formula: C14H13ClF2Si
• Molecular Weight: 282.793
• DSSTox Substance ID: DTXSID901206400
• Nikkaji Number: J2.905.789C
• Mol file: 85491-26-5.mol

Synonyms:Bis(4-fluorophenyl)methyl(chloromethyl)silane;Silane, (chloromethyl)bis(4-fluorophenyl)methyl-;SCHEMBL9358733;DTXSID901206400;Methyl(chloromethyl)bis(4-fluorophenyl)silane;1,1'-[(Chloromethyl)methylsilylene]bis[4-fluorobenzene]

Chemical Property of Silane, (chloromethyl)bis(4-fluorophenyl)methyl-

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Boiling Point: 107℃ (0.001 Torr)
• PSA: 0.00000
• LogP: 3.35390
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 282.0443110
• Heavy Atom Count: 18
• Complexity: 237

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Hazard Codes: N
• Statements: 51/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](CCl)(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F

Technology Process of Silane, (chloromethyl)bis(4-fluorophenyl)methyl-

There total 2 articles about Silane, (chloromethyl)bis(4-fluorophenyl)methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) + chloromethylmethyldichlorosilane (1558-33-4) → (chloromethyl)bis(4-fluorophenyl)methylsilane (85491-26-5)

Guidance literature:

1-Bromo-4-fluorobenzene; With magnesium; In tetrahydrofuran; at 32 - 60 ℃; for 2.5h; Large scale;

chloromethylmethyldichlorosilane; In tetrahydrofuran; at 40 ℃; for 2h; Temperature; Concentration; Large scale;

Reference yield:

chloromethyl(dichloro)methylsilane + 1-Bromo-4-fluorobenzene (460-00-4) → (chloromethyl)bis(4-fluorophenyl)methylsilane (85491-26-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield: 92.0%

sodium triazole (41253-21-8) + (chloromethyl)bis(4-fluorophenyl)methylsilane (85491-26-5) → Flusilazole (85509-19-9)

Guidance literature:

In N,N-dimethyl-formamide; at 65 - 70 ℃; for 3h;

upstream raw materials:

1-Bromo-4-fluorobenzene

chloromethylmethyldichlorosilane

Downstream raw materials:

Flusilazole