41253-21-8

Usage

Uses

Used in Wood Preservation Industry:
1,2,4-Triazolylsodium is used as an antimycotic agent for inhibiting mold growth on unseasoned pine. Its application helps protect wood from fungal infestations, ensuring the longevity and quality of the material.
Used in Agricultural Industry:
1,2,4-Triazolylsodium can also be employed as a fungicide in the agricultural sector, where it helps prevent the growth of mold and other fungi on crops, thus improving crop yield and quality.
Used in Pharmaceutical Industry:
Due to its antimycotic properties, 1,2,4-Triazolylsodium may be utilized in the development of antifungal medications, targeting a range of fungal infections in humans and animals.
Used in Cosmetics Industry:
In the cosmetics industry, 1,2,4-Triazolylsodium can be used as a preservative to prevent the growth of mold and other fungi in various cosmetic products, ensuring their safety and shelf life.
Used in Food Industry:
As a fungicide, 1,2,4-Triazolylsodium can be applied in the food industry to prevent mold growth on perishable items, extending their shelf life and maintaining their quality for consumers.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C2H3N3.Na/c1-3-2-5-4-1;/h1-2H,(H,3,4,5);/q;+1

Upstream product

• 288-88-0 1,2,4-Triazole 
• 951-78-0 2'-deoxyuridine 
• 141-52-6 sodium ethanolate 
• 80991-41-9 1-(3,5-Di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone 
• 872-50-4 1-methyl-pyrrolidin-2-one 

Downstream Products

• 131885-76-2 2-nitro-5-(1,2,4-triazol-1-yl)aniline 
• 129500-97-6 2-(4-chlorophenyl)-3-(1H-1,2,4-triazol-1-yl)cyclohept-1-ene 
• 100199-06-2 (1R,2R)-1-(5-Chloro-thiophen-2-yl)-2-[1,2,4]triazol-1-yl-cyclohexanol 
• 100199-31-3 trans-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexanol 
• 89219-16-9 trans-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexanol 
• 100199-27-7 trans-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol 
• 3277-80-3 (4-chlorophenyl)(cyclohexyl)methanone 
• 129500-98-7 1-(4-chlorophenyl)cyclohept-2-en-1-ol 
• 130235-42-6 1-(2,4-dichlorophenyl)-1-(2-thiolen-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol 
• 130235-28-8 1-(2,4-dichlorophenyl)-1-(2-methylthiolan-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol 
• 130235-27-7 erythro-1-(4-chlorophenyl)-1-(2-thiolanyl)-2-(1H-1,2,4-triazol-1-yl)ethanol 
• 130235-27-7 threo-1-(4-chlorophenyl)-1-(2-thiolanyl)-2-(1H-1,2,4-triazol-1-yl)ethanol 
• 130235-26-6 erythro-1-(2,4-dichlorophenyl)-1-(2-thiolanyl)-2-(1H-1,2,4-triazol-1-yl)ethanol 
• 130235-26-6 threo-1-(2,4-dichlorophenyl)-1-(2-thiolanyl)-2-(1H-1,2,4-triazol-1-yl)ethanol 

Relevant academic research and scientific papers

Carcinogenic Alkylation of Nucleic Acid Bases. Structure and Conformation of O4-Ethyl-2'-deoxythymidine in the Solid State and in Solution

O4-Ethyl-2'-deoxythymidine (e4dT) crystallizes in the monoclinic space group P21, and the cell dimensions are a = 5.079(1) Angstroem, b = 15.054(1) Angstroem, c = 8.467(1) Angstroem, β = 94.07(1) deg.X-ray intensity data were measured with a diffractometer, and the structure was solved by direct methods.Least-squares refinement, which included all hydrogen atoms; converged at R = 0.030 for 1365 observed reflections.The O-ethyl group is coplanar with the pyrimidine ring, the methylene carbon atom being syn to N3.It is shown that O4-alkylation causes significant changes in the geometry of the ring which can be attributed to an altered electronic structure.The conformation about the glycosidic bond is anti with χCN = 22.8 deg.The deoxyribose ring dopts the unusual C3' endo/C2' exo twist pucker, and the gauche(1+) rotamer of the CH2OH side chain is stabilized by an intramolecular C6-H...O5' hydrogen bond.Proton NMR data for e4dT and e4dU reveal the usual preference for the C2' endo sugar pucker and a conformer distribution for the C4'-C5' bond which is expected for 2'-deoxyribosides.Comments are made on the relevance of the structure to base mispairing of O-alkyl pyrimidines and their enzymatic repair.

AZOLE DERIVATIVE, METHOD FOR PRODUCING AZOLE DERIVATIVE, AND INTERMEDIATE COMPOUND

In order to provide a novel azole derivative, an azole derivative of the present invention is an azole derivative represented by a general formula (V'). (where R6 and R7 independently represent a hydrogen atom, a C1-C4 alkyl group, a phenyl group, or a benzyl group; X represents a halogen atom, a C1-C4 alkyl group, a haloalkyl group, an alkoxy group or a haloalkoxy group, a phenyl group, a cyano group, or a nitro group; m represents an integer of 0 to 5; and A represents a nitrogen atom or a methyne group.)

Triazole antifungal agents

New triazole antifungal agents having C6S7 or S6C7 bridges are disclosed. These triazoles provide alternatives to existing antifungals in terms of formulation, bioavailability and activity.

PROCESS FOR THE PREPARATION OF ANTICANCER DRUGS

A process for preparing Anastrozole is provided. In the process the steps of a. combining 3,5-bis (2-cyanoisopropyl)toluene, a solvent selected from the group consisting of acetonitrile, dichloromethane and chlorobenzene, a brominating reagent selected from a group consisting of N-bromosuccinimide and l,3-dibromo-5,5-dimethylhydantoin, and 2,2'- azobis(2-methylpropionitrile); b. heating; c. combining with 1,2,4-triazole, a solvent selected from a group consisting of N-methylpyrrolidine, dimethylformamide, mixtures of NMP and DMF, dimethylsulfoxide, mixtures of DMSO and toluene, acetone, ACN, and tetrahydrofuran, a base selected from a group consisting of NaOH, KOH, K2CO3, and Na2CO3, and l,3-benzendiacetonitrile-5- (bromomethyl)-α, α, ?, ?- tetramethyl, at a temperature below -20°C are performed.

IMPROVED PROCESS FOR THE PREPARATION OF RIZATRIPTAN BENZOATE

Present invention discloses an improved and commercially viable process for the preparation of rizatriptan benzoate of formula (I). According to the present process the hydrazone intermediate derived from the phenylhydrazine of formula- (III) and 4- dimethylaminobutyraldehyde diethyl acetal is gradually heated to 60-70 °C in aqueous sulfuric acid medium and maintained for 3-4hr to get rizatriptan with less dimeric impurity of formula (X). The resultant rizatriptan is isolated and converted into the pharmaceutically acceptable benzoate salt. Present process produces less percentage of dimeric (less than 3 %) or polymeric impurities compared to the prior art process and more yield of rizatriptan. Rizatriptan benzoate produced according to the present process has more than 99.5 % purity with less than 0.1% dimeric impurity of formula (X) by HPLC. Rizatriptan benzoate is useful for the treatment of migraine.

IMPROVED PROCESS FOR THE PREPARATION OF HIGH PURITY ANASTROZOLE

Present invention discloses an improved process for the preparation of high purity anastrozole of formula-I (2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropio-nitrile) consisting of: (i) halogenation of 5, α, α, α', α'-pentamethyl-1,3-benzenediacetonitrile; (ii) reaction with sodium/potassium triazole; (iii) purification of crude anastrozole (containing more than 1% of triazole isomeric impurity) through salt formation; and (iv) isolation of pure anastrozole from its salts. It is observed that the removal of triazole isomeric impurity is possible only through a salt formation.

Isocyanates containing uretdione groups

The invention relates to novel compounds containing uretdione groups, to a process for preparing them by dimerizing aliphatic and/or cycloaliphatic isocyanates containing exclusively secondary and/or tertiary isocyanate groups and also to the use of uretdione polyisocyanates obtainable by this process from diisocyanates containing exclusively secondary and/or tertiary isocyanate groups as a starting component for polyurethane polymers, in particular as an isocyanate component in the preparation of uretdione powder coating crosslinkers.

Method of dimerizing isophorone diisocyanate

The invention relates to a method of preparing a polyisocyanate with at least one uretdione group by oligomerizing part of the isocyanate groups of isophorone diisocyanate in the presence of a catalyst which accelerates the dimerization of isocyanate groups, wherein the oligomerization catalyst comprises a saline compound comprising from 10 to 100 wt. % of 1,2,3- and/or 1,2,4-triazolate structures (calculated as C2N3; molecular weight=66) in the anion, and the products prepared by this method.

Production methods of epoxytriazole derivative and intermediate therefor

An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base. wherein Ar is a phenyl group optionally substituted by 1 to 3 halogen atom(s) or trifluoromethyl group, R is a hydrogen atom or lower alkyl group, and X is a leaving group.

Synthesis of Fungicidal (1H-1,2,4-Triazol-1-yl-methyl)silanes and -siloxanes

The synthesis of FlusilazoleTM (1a) was substantially improved by thorough exclusion of oxygen nucleophiles in the reaction of (chloromethyl)bis(4-fluorophenyl)methylsilane with sodium 1H-1,2,4-triazolide.New α,α-diaryl-α-(1H-1,2,4-triazol-1-yl-methyl)siloxanes 3 were obtained firstly from diaryl(1H-1,2,4-triazol-1-yl-methyl)silanols or -silanolates, which were prepared by different methods from the corresponding silanol hydrochlorides and further treated with functional, linear oligodimethylsiloxanes or secondly from α,α-diaryl-α-(chloromethyl)siloxanes and 1-(trimethylsilyl)-1H-1,2,4-triazole.The siloxane 4 containing a triazolylmethyl group and additionally silicofunctional coupling groups could be synthesized by hydrosilylation of an α-triazolylmethyl-ω-vinylsiloxane with triethoxysilane. - Key Words: Fungicides / Silanes / Siloxanes / 1,2,4-Triazoles