(2S)-3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}propane-1,2-diol

Base Information

Chemical Name:(2S)-3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}propane-1,2-diol
CAS No.:85648-10-8
Molecular Formula:C13H21NO4
Molecular Weight:255.314
Hs Code.:
DSSTox Substance ID:DTXSID20512135
Wikidata:Q82371246

Synonyms:85648-10-8;SCHEMBL9700731;DTXSID20512135;(2S)-3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}propane-1,2-diol

Suppliers and Price of (2S)-3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}propane-1,2-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (2S)-3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}propane-1,2-diol

Chemical Property:

XLogP3:0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:255.14705815
Heavy Atom Count:18
Complexity:215

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CCNCC(CO)O)OC
Isomeric SMILES:COC1=C(C=C(C=C1)CCNC[C@@H](CO)O)OC

Technology Process of (2S)-3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}propane-1,2-diol

There total 5 articles about (2S)-3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 85613-46-3
2-Phenyl-3-cyclopropyl-5-(hydroxymethyl)-oxazolidine

: 85648-10-8
(S)-3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-1,2-propanediol

Guidance literature:

Reference yield:

: 3-(2-Ethoxyethyl)amino-1,2-propanediol

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 85613-46-3
2-Phenyl-3-cyclopropyl-5-(hydroxymethyl)-oxazolidine

: 85648-10-8
(S)-3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-1,2-propanediol

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; Pb(OAc)4; In tetrahydrofuran; sodium hydroxide; chloroform;

Reference yield:

: [2-(3,4-Dimethoxy-phenyl)-ethyl]-[1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-amine

: 85648-10-8
(S)-3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-1,2-propanediol

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄, 4percent NaOH / tetrahydrofuran / 1.) 0-4 deg C, 0.5 h, 2.) RT, 1.5 h

2: 2 N HCl / 18 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; In tetrahydrofuran;
DOI:10.1021/jm00361a004