85613-46-3

Upstream product

• 100-52-7 benzaldehyde 
• 85613-41-8 3-Cyclopropylamino-1,2-propanediol 
• 126007-94-1 2-Phenyl-3-(2-ethoxyethyl)-5-(hydroxymethyl)-oxazolidine 
• 7732-18-5 water 
• 67-56-1 methanol 
• 131543-46-9 Glyoxal 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 96-26-4 dihydroxyacetone 
• 126007-80-5 2-{p-[3-(2-ethoxyethyl)amino-2-hydroxypropoxy]phenyl}-4-(thien-2-yl)imidazole 
• 91944-29-5 (S) 3-cyclopropylamino-1,2-propanediol 

Downstream Products

• 85648-10-8 (S)-3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-1,2-propanediol 
• 66781-20-2 (S) 2-phenyl-3-[2-(3,4-dimethoxyphenyl)ethyl]-5-hydroxymethyloxazolidine 
• 85648-12-0 (S)-1-Cyclopropylamino-3-[4-(5-thiophen-2-yl-1H-imidazol-2-yl)-phenoxy]-propan-2-ol 
• 91944-30-8 (S)-p-<3-(cyclopropylamino)-2-hydroxypropoxy>benzaldehyde 
• 85613-34-9 Toluene-4-sulfonic acid (S)-3-cyclopropyl-2-phenyl-oxazolidin-5-ylmethyl ester 
• 91944-27-3 (+/-)-2-{p-[3-(cyclopropylamino)-2-hydroxypropoxy]phenyl}-4-(2-thienyl)imidazole 
• 85613-55-4 1-Cyclopropylamino-3-[4-(5-methyl-1H-imidazol-2-yl)-phenoxy]-propan-2-ol 
• 85613-34-9 2-phenyl-3-cyclopropyl-5-(hydroxymethyl)oxazolidine tosylate 
• 52353-63-6 4-Hydroxymethyl-2-(4-hydroxyphenyl)-imidazole 

Relevant academic research and scientific papers

BETA-BLOCKING SUBSTITUTED IMIDAZOLES

Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity.

BETA-ADRENERGIC BLOCKING IMIDAZOLYLPHENOXY PROPANOLAMINES

Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity. STR1

3-AMINO-2-HYDROXYPROPOXYARYL IMIDAZOLE DERIVATIVES

Novel substituted imidazoles of the formula STR1 and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity.

β1-Selective adrenoceptor antagonists: Examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class

A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for β-adrenoceptor antagonism, and several examples were found to be selective for the β1-adrenoceptor. The structure-activity relationship exhibited by this series of compounds is discussed. (S)-2-[p-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]phenyl] -4-(2-thienyl)imidazole [(S)-13] was over 100 times more selective than atenolol for the β1-adrenergic receptor and has been selected for in-depth studies.