Imidazo[1,5-A]pyridine-5-carbaldehyde

Base Information

• Chemical Name: Imidazo[1,5-A]pyridine-5-carbaldehyde
• CAS No.: 85691-71-0
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• European Community (EC) Number: 868-316-9
• DSSTox Substance ID: DTXSID60527682
• Wikidata: Q82396900
• Mol file: 85691-71-0.mol

Synonyms:IMIDAZO[1,5-A]PYRIDINE-5-CARBALDEHYDE;85691-71-0;5-formylimidazol[1,5-a]pyridine;IMIDAZO[1,5-A]PYRIDINE-5-CARBOXALDEHYDE;Imidazo[1,5-a]pyridine-5-carboxaldehyde (9CI);SCHEMBL10645381;5-formylimidazo[1,5-a]pyridine;DTXSID60527682;JTPBTUUKUMKNHD-UHFFFAOYSA-N;5-formylimidazo-[1,5-a]pyridine;MFCD06739250;AKOS006292623;AB28967;BS-24307;CS-0183262;EN300-299099;P19168;A863473;J-517812;Z1198169962

Chemical Property of Imidazo[1,5-A]pyridine-5-carbaldehyde

Chemical Property:

• PKA: 5.97±0.30(Predicted)
• PSA: 34.37000
• Density: 1.24g/cm3
• LogP: 1.14680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 146.048012819
• Heavy Atom Count: 11
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

Imidazo[1,5-a]pyridine-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CN=CN2C(=C1)C=O

Technology Process of Imidazo[1,5-A]pyridine-5-carbaldehyde

There total 9 articles about Imidazo[1,5-A]pyridine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

imidazo [1,5-a]pyridin-5-ylmethanol → 5-formylimidazo<1,5-a>pyridine (85691-71-0)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; water; at 20 ℃; for 5h;

Reference yield:

5-formyl-3-ethylthioimidazo[1,5-a]pyridine → 5-formylimidazo<1,5-a>pyridine (85691-71-0)

Guidance literature:

aluminum nickel; In diethyl ether; ethyl acetate; isopropyl alcohol;

Reference yield:

6-(aminomethyl)pyridine-2-carboxylic acid ethyl ester (104086-21-7) → 5-formylimidazo<1,5-a>pyridine (85691-71-0)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic anhydride / 4 h / 80 °C

2: trichlorophosphate / toluene / 2 h / 80 °C

3: sodium tetrahydroborate / ethanol / 1 h / 80 °C

4: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane; water / 5 h / 20 °C

With sodium tetrahydroborate; acetic anhydride; sodium hydrogencarbonate; Dess-Martin periodane; trichlorophosphate; In ethanol; dichloromethane; water; toluene;

upstream raw materials:

6-(aminomethyl)pyridine-2-carboxylic acid ethyl ester

ethyl imidazo [1,5-a]pyridine-5-carboxylate

diethyl-2,6-pyridinedicarbonyl ester

ethyl 6-(hydroxymethyl)pyridine-2-carboxylate