tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxy-1-(pyridin-4-yl)butan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxy-1-(pyridin-4-yl)butan-2-yl]carbamate
CAS No.:162538-25-2
Molecular Formula:C₂₉H₄₄N₄O₆
Molecular Weight:544.692
Hs Code.:

tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxy-1-(pyridin-4-yl)butan-2-yl]carbamate

Synonyms:12-Oxa-2,6,10-triazatetradecanoicacid,4,8-dihydroxy-13,13-dimethyl-11-oxo-3-(phenylmethyl)-9-(4-pyridinylmethyl)-,1,1-dimethylethyl ester, [3S-(3R*,4S*,8S*,9R*)]-

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Chemical Property of tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxy-1-(pyridin-4-yl)butan-2-yl]carbamate

Chemical Property:

Vapor Pressure:5.64E-22mmHg at 25°C
Boiling Point:723.6°Cat760mmHg
Flash Point:391.4°C
PSA：149.02000
Density:1.158g/cm³
LogP:3.76450

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxy-1-(pyridin-4-yl)butan-2-yl]carbamate

There total 7 articles about tert-butyl [(2S,3R)-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxy-1-(pyridin-4-yl)butan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.8%

: ((S)-1-Oxiranyl-2-pyridin-4-yl-ethyl)-carbamic acid tert-butyl ester

: 246047-29-0
((S)-3-Amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert-butyl ester

: 162538-25-2
[(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-pyridin-4-ylmethyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 4h;
DOI:10.1021/jm950717a

Reference yield:

: 37535-57-2
(S)-2-((tert-butoxycarbonyl)amino)-3-(pyridin-4-yl)propanoic acid

: 162538-25-2
[(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-pyridin-4-ylmethyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 4-methylmorpholine / tetrahydrofuran

2: tetrahydrofuran; diethyl ether / 0 °C

3: HCl / dioxane / 0 °C

4: NaBH₄

5: KOH / ethanol

6: 4.8 percent / dimethylformamide / 4 h / 100 °C

With 4-methyl-morpholine; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a

Reference yield:

: ((S)-3-Chloro-2-hydroxy-1-pyridin-4-ylmethyl-propyl)-carbamic acid tert-butyl ester

: 162538-25-2
[(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-pyridin-4-ylmethyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / ethanol

2: 4.8 percent / dimethylformamide / 4 h / 100 °C

With potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a