Chemical Property of 2-Bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
Chemical Property:
- Melting Point:230 °C
- Boiling Point:470.3±45.0 °C(Predicted)
- PKA:8.57±0.31(Predicted)
- PSA：76.50000
- Density:1.576±0.06 g/cm3(Predicted)
- LogP:3.93170
- Storage Temp.:Store at RT
- Solubility.:DMSO: soluble1mg/mL, clear (warmed)
- XLogP3:3.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:4
- Exact Mass:375.02185
- Heavy Atom Count:23
- Complexity:390
- Purity/Quality:
-
99%, *data from raw suppliers
WHI-P154 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26
- MSDS Files:
-
Useful:
- Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC
-
Description
WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 μM versus IC50s > 10 μM for JAK1 and JAK2). It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and Src. WHI-P154 is cytotoxic to human glioblastoma cells (IC50 = 813 nM) and has been used to induce the differentiation of neuronal precursor cells.
-
Uses
WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM. WHI-P154 can act as antileukemic agent with apoptosis inducing activity.
