1-Piperidinehexanoic acid, 4-[bis(phenylmethyl)amino]-3-methoxy-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (3S,4R)-

Base Information

Chemical Name:1-Piperidinehexanoic acid, 4-[bis(phenylmethyl)amino]-3-methoxy-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (3S,4R)-
CAS No.:860169-80-8
Molecular Formula:C33H47N3O3
Molecular Weight:533.754
Hs Code.:

Synonyms:

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Chemical Property of 1-Piperidinehexanoic acid, 4-[bis(phenylmethyl)amino]-3-methoxy-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (3S,4R)-

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Technology Process of 1-Piperidinehexanoic acid, 4-[bis(phenylmethyl)amino]-3-methoxy-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (3S,4R)-

There total 17 articles about 1-Piperidinehexanoic acid, 4-[bis(phenylmethyl)amino]-3-methoxy-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 860169-77-3
ethyl 6-((3S,4R)-4-(dibenzylamino)-3-methoxypiperidin-1-yl)hexanoate

: 25333-42-0
(R)-quinuclidin-3-ol

: 860169-80-8
(R)-quinuclidin-3-yl 6-((3S,4R)-4-(dibenzylamino)-3-methoxypiperidin-1-yl)hexanoate

Guidance literature:: With titanium(IV) tetraethanolate; In toluene; at 0 - 90 ℃; for 18h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 860169-74-0
(3S,4R)-N,N-dibenzyl-3-methoxypiperidin-4-amine

: 1000027-25-7
C₁₃H₂₂BrNO₂*ClH

: 860169-80-8
(R)-quinuclidin-3-yl 6-((3S,4R)-4-(dibenzylamino)-3-methoxypiperidin-1-yl)hexanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 11h; Product distribution / selectivity;

Reference yield:

: 100-39-0
benzyl bromide

: 860169-80-8
(R)-quinuclidin-3-yl 6-((3S,4R)-4-(dibenzylamino)-3-methoxypiperidin-1-yl)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C

2.1: sodium hydroxide; isopropyl alcohol / 3 - 5 h / Heating / reflux

3.1: O,O'-dibenzoyl-L-tartaric acid / ethanol / 20 °C / Heating / reflux

3.2: 20 °C / pH 12

4.1: potassium carbonate / N,N-dimethyl-formamide / 11 h / 70 °C

With sodium hydroxide; potassium carbonate; isopropyl alcohol; O,O'-dibenzoyl-L-tartaric acid; potassium iodide; In ethanol; N,N-dimethyl-formamide;