1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 2-[(1,1-dimethylethoxy)carbonyl]-1-(6-heptenyl)hydrazide, (2S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 2-[(1,1-dimethylethoxy)carbonyl]-1-(6-heptenyl)hydrazide, (2S,4R)-
CAS No.:862120-13-6
Molecular Formula:C42H53N5O8
Molecular Weight:755.912
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4-
[(7-methoxy-2-phenyl-4-quinolinyl)oxy]-,
2-[(1,1-dimethylethoxy)carbonyl]-1-(6-heptenyl)hydrazide, (2S,4R)-

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 2-[(1,1-dimethylethoxy)carbonyl]-1-(6-heptenyl)hydrazide, (2S,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 2-[(1,1-dimethylethoxy)carbonyl]-1-(6-heptenyl)hydrazide, (2S,4R)-

There total 3 articles about 1-Pyrrolidinecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinolinyl)oxy]-, 2-[(1,1-dimethylethoxy)carbonyl]-1-(6-heptenyl)hydrazide, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 75-44-5
phosgene

: 862118-91-0
N'-hept-6-enyl-hydrazinecarboxylic acid tert-butyl ester

: 793661-43-5
1-{[4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

: 862120-13-6
1-{[1-(N'-tert-butoxycarbonyl-N-hept-6-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: phosgene; 1-{[4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester; With sodium hydrogencarbonate; In tetrahydrofuran; for 0.5h;

N'-hept-6-enyl-hydrazinecarboxylic acid tert-butyl ester; With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 40h;