1-(4-Tert-butylphenyl)-3-azabicyclo[3.1.0]hexane

Base Information

Chemical Name:1-(4-Tert-butylphenyl)-3-azabicyclo[3.1.0]hexane
CAS No.:86215-71-6
Molecular Formula:C15H21N
Molecular Weight:215.338
Hs Code.:
ChEMBL ID:CHEMBL1193852
DSSTox Substance ID:DTXSID30507971

Synonyms:86215-71-6;1-(4-tert-butylphenyl)-3-azabicyclo[3.1.0]hexane;SCHEMBL5420499;CHEMBL1193852;DTXSID30507971

Suppliers and Price of 1-(4-Tert-butylphenyl)-3-azabicyclo[3.1.0]hexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-Tert-butylphenyl)-3-azabicyclo[3.1.0]hexane

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:215.167399674
Heavy Atom Count:16
Complexity:270

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=CC=C(C=C1)C23CC2CNC3

Technology Process of 1-(4-Tert-butylphenyl)-3-azabicyclo[3.1.0]hexane

There total 8 articles about 1-(4-Tert-butylphenyl)-3-azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 77053-90-8
1-(p-tert.-butylphenyl)-1,2-cyclopropanedicarboximide

: 86215-71-6
1-(4-(tert-butyl)phenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene; for 2h; Heating;
DOI:10.1021/jm00137a002

Reference yield:

: tert-butyl 1-(4-(tert-butyl)phenyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 86215-71-6
1-(4-(tert-butyl)phenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 3549-23-3
methyl 2-(4-tert-butylphenyl)acetate

: 86215-71-6
1-(4-(tert-butyl)phenyl)-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / NBS, 48percent aq. HBr / CCl₄ / Heating

2: 60 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

3: 96 percent / KOH / ethanol; H₂O / 6 h / Heating

4: 37 percent / urea / xylene / Heating

5: 45 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating

With potassium hydroxide; N-Bromosuccinimide; hydrogen bromide; sodium methylate; sodium bis(2-methoxyethoxy)aluminium dihydride; urea; In tetrachloromethane; diethyl ether; ethanol; water; xylene; benzene;
DOI:10.1021/jm00137a002