3549-23-3Relevant articles and documents
Production method of methyl p-tert-butylphenylacetate
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Paragraph 0017-0032, (2022/01/08)
The invention discloses a production method of methyl p-tert-butylphenylacetate. The method takes p-tert-butylphenylacetic acid and absolute methanol as initial raw materials, and comprises the following reaction operations: heating and refluxing for esterifying and dehydrating p-tert-butylphenylacetic acid and absolute methanol as raw materials under the catalytic action of trifluoromethanesulfonic acid, after the reaction is completed, distilling excessive methanol, cooling residues to room temperature, washing an organic phase once by using a saturated saline solution, standing for layering, separating a water phase, combining the organic phases, neutralizing the organic phases by using 10% sodium carbonate liquid until the pH value is 7-8, standing for layering, separating the water phase, desolventizing the organic phases to the bottom temperature of 80 DEG C, cooling to obtain a crude product, carrying out reduced pressure rectification, and collecting fractions at 122-124 DEG C/1.2 Kpa to obtain the finished product of the methyl p-tert-butylphenylacetate. The raw materials are easy to obtain and low in price, conditions are easy to control and operate, and the product is low in cost, good in quality and suitable for large-scale production.
B(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes
Guo, Jing,Mandal, Dipendu,Stephan, Douglas W.,Wu, Yile,Zhao, Yunbo
supporting information, p. 7758 - 7761 (2021/08/13)
Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes is described in the presence of 10 mol% of B(C6F5)3. These reactions provide N1-alkylated benzotriazoles in good to excellent yields and this protocol is successfully adapted to gram-scale syntheses as well as a derivative with antimicrobial activity.
Palladium-Catalyzed Carbonylative Direct Transformation of Benzyl Amines under Additive-Free Conditions
Li, Yahui,Wang, Zechao,Wu, Xiao-Feng
, p. 738 - 741 (2018/01/17)
In this communication, we developed a new procedure for the direct carbonylative transformation of benzyl amines. Using dimethyl carbonate as the solvent, methyl 2-arylacetates can be produced in good to excellent yields from the corresponding primary, secondary, and tertiary benzyl amines with palladium as the catalyst. Notably, no base or any other additive is required here. In addition, our procedure can also be applied in the preparation of methylphenidate, which is a marketing drug and used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.