Chemical Property of Olvanil
Chemical Property:
- Vapor Pressure:8.33E-15mmHg at 25°C
- Melting Point:36 °C
- Refractive Index:1.508
- Boiling Point:596.1 °C at 760 mmHg
- PKA:9.76±0.20(Predicted)
- Flash Point:314.3 °C
- PSA：58.56000
- Density:0.982 g/cm3
- LogP:7.44540
- Storage Temp.:−20°C
- Solubility.:H2O: <0.2mg/mL
- XLogP3:8.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:18
- Exact Mass:417.32429423
- Heavy Atom Count:30
- Complexity:438
- Purity/Quality:
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99% *data from raw suppliers
Olvanil *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CCCCCCCCC=CCCCCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
- Isomeric SMILES:CCCCCCCC/C=C\CCCCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
- Recent ClinicalTrials:Effect of Olvanil Supplementation on Clinical, Biochemical and Anthropometric Parameters in Obese Adults
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Description
Olvanil is a structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus. It is the amide of vanillylamine and oleic acid. Olvanil acts as an agonist at the vanilloid receptor, VR1, inducing desensitization analgesia in rat and mouse models of pain. Olvanil has complex interactions with the cannabinoid system, in that it potentiates the agonist activity of endogenous cannabinoids by inhibiting the reuptake of arachidonyl ethanolamide (AEA). Olvanil is a more potent reuptake inhibitor than AM404, which is commonly used for this purpose (50% inhibition of reuptake at 10 μM versus 12% for AM404 at the same dose). Olvanil is also a CB1 agonist, but does not bind to CB2 receptors or inhibit fatty acid amide hydrolase. The overall activity of olvanil in most models is that of an analgesic, but it is unclear how these effects are mediated by VR1, the CB1 receptor, or other components of the endogenous pain sensation system.
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Uses
Analgesic. Olvanil is a TRPV1 agonist more potent than capsaicin.
