Thieno[3,2-c]pyridine-2-carboxylic acid

Base Information

• Chemical Name: Thieno[3,2-c]pyridine-2-carboxylic acid
• CAS No.: 86236-37-5
• Molecular Formula: C₈H₅NO₂S
• Molecular Weight: 179.199
• Hs Code.: 2934999090
• Mol file: 86236-37-5.mol

Synonyms:2-carboxythieno[3,2-c]pyridine;

Chemical Property of Thieno[3,2-c]pyridine-2-carboxylic acid

Chemical Property:

• Boiling Point: 418.3±25.0 °C(Predicted)
• PKA: 2.48±0.30(Predicted)
• PSA: 78.43000
• Density: 1.508±0.06 g/cm3(Predicted)
• LogP: 1.99450

Purity/Quality:

95%+ ^*data from raw suppliers

Thieno[3,2-C]pyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thieno[3,2-c]pyridine-2-carboxylic acid

There total 6 articles about Thieno[3,2-c]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

methyl thieno[3,2-c]pyridine-2-carboxylate (478149-07-4) → thieno[3,2-c]pyridine-2-carboxylic acid (86236-37-5)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In methanol; water;

Reference yield:

ethylthieno[3,2-c]pyridine-2-carboxylate → thieno[3,2-c]pyridine-2-carboxylic acid (86236-37-5)

Guidance literature:

With water; lithium hydroxide; In methanol; at 70 ℃; for 2h;

Reference yield:

thieno[3,2-c]pyridine (272-14-0) + n-butyllithium (109-72-8,29786-93-4) + carbon dioxide (124-38-9,18923-20-1) → thieno[3,2-c]pyridine-2-carboxylic acid (86236-37-5)

Guidance literature:

With diisopropylamine; In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; acetone;

upstream raw materials:

methyl thieno[3,2-c]pyridine-2-carboxylate

thieno[3,2-c]pyridine

n-butyllithium

carbon dioxide

Downstream raw materials:

1-(thieno[3,2-c]pyridin-2-yl)ethan-1-one

Refernces

• 1、 -. "CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR". Page/Page column 15. . Retrieved 2012/10/08.
• 2、 -. "Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease". . . Retrieved 2008/06/13.