Technology Process of (R)-N-(2-Acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl)acetamide
There total 11 articles about (R)-N-(2-Acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenyl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
aluminium amalgam;
In
tetrahydrofuran; water;
for 0.5h;
Ambient temperature;
DOI:10.1021/jo00229a010
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 98.7 percent / ammonium carbonate / ethanol; H2O / 1 h / Heating
2: 92 percent / barium hydroxide octahydrate / H2O / 36 h / Heating
3: 94.9 percent / HCl (g) / 24 h / 25 °C
5: 1.) sodium hydride / 1.) THF, 65 deg C, 1.5 h, 2.) THF, 5 deg C - 10 deg C, 1 h
6: aq. sodium hydroxide, zinc / toluene / 2 h / 65 °C
7: pyridine / 1.) 20 deg C, 1 h, 2.) 70 deg C, 30 min
With
pyridine; ammonium carbonate; hydrogenchloride; sodium hydroxide; barium hydroxide octahydrate; sodium hydride; zinc;
In
ethanol; water; toluene;
DOI:10.1021/jo00229a010
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 92 percent / barium hydroxide octahydrate / H2O / 36 h / Heating
2: 94.9 percent / HCl (g) / 24 h / 25 °C
4: 1.) sodium hydride / 1.) THF, 65 deg C, 1.5 h, 2.) THF, 5 deg C - 10 deg C, 1 h
5: aq. sodium hydroxide, zinc / toluene / 2 h / 65 °C
6: pyridine / 1.) 20 deg C, 1 h, 2.) 70 deg C, 30 min
With
pyridine; hydrogenchloride; sodium hydroxide; barium hydroxide octahydrate; sodium hydride; zinc;
In
water; toluene;
DOI:10.1021/jo00229a010
