(R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

Base Information

Chemical Name:(R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione
CAS No.:104319-02-0
Molecular Formula:C₂₂H₁₉NO₆
Molecular Weight:393.396
Hs Code.:

Synonyms:(R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

Suppliers and Price of (R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

Chemical Property:

Melting Point:>300 °C
Boiling Point:721.1±60.0 °C(Predicted)
Density:1.49±0.1 g/cm3(Predicted)

Purity/Quality:: 99%, ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

There total 1 articles about (R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 85-44-9
phthalic anhydride

: 86264-61-1
(R)-(-)-2-acetyl-2-acetamido-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene

: 104319-02-0
(R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

Guidance literature:: With aluminium trichloride; sodium chloride; at 170 ℃; for 0.0666667h;
DOI:10.1021/jo00229a010

Reference yield: 88.0%

: 107-21-1
ethylene glycol

: 104319-02-0
(R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

: 86264-76-8
(R)-(-)-9-acetamido-9-<1,1-(ethylenedioxy)ethyl>-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 4h; Heating;
DOI:10.1021/jo00229a010

Reference yield:

: 104319-02-0
(R)-(-)-9-acetyl-9-acetamido-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

: 110267-81-7
Amrubicin

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / p-toluenesulfonic acid / toluene / 4 h / Heating

2: 88.5 percent / 1,3-dibromo-5,5-dimethylhydantoin / benzene / 0.25 h / Heating; Irradiation

3: 81.8 percent / 3 N aq. H₂SO₄ / 30 h / 80 °C

4: 86 percent / tetramethylurea, silver trifluoromethanesulfonate / CH₂Cl₂; diethyl ether / 0.5 h / 0 - 5 °C

5: 90 percent / potassium carbonate / methanol; CH₂Cl₂ / 18 h / -5 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; silver trifluoromethanesulfonate; potassium carbonate; toluene-4-sulfonic acid; tetramethylurea; In methanol; diethyl ether; dichloromethane; toluene; benzene;
DOI:10.1021/jo00229a010