2(1H)-Pyridinone, 5-[(4-fluorophenyl)methyl]-3-nitro-

Base Information

Chemical Name:2(1H)-Pyridinone, 5-[(4-fluorophenyl)methyl]-3-nitro-
CAS No.:863443-02-1
Molecular Formula:C12H9FN2O3
Molecular Weight:248.213
Hs Code.:

Synonyms:2(1H)-PYRIDINONE,5-[(4-FLUOROPHENYL)METHYL]-3-NITRO;5-[(4-fluorophenyl)methyl]-3-nitro-2(1H)-pyridone;5-[(4-fluorophenyl)methyl]-3-nitro-2(1H)-pyridinone;

Suppliers and Price of 2(1H)-Pyridinone, 5-[(4-fluorophenyl)methyl]-3-nitro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2(1H)-Pyridinone, 5-[(4-fluorophenyl)methyl]-3-nitro-

Chemical Property:

PSA：78.94000
LogP:2.94850

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyridinone, 5-[(4-fluorophenyl)methyl]-3-nitro-

There total 4 articles about 2(1H)-Pyridinone, 5-[(4-fluorophenyl)methyl]-3-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 863443-01-0
5-[(4-fluorophenyl)methyl]-2(1H)-pyridinone

: 863443-02-1
5-[(4-fluorophenyl)methyl]-3-nitro-2(1H)-pyridinone

Guidance literature:: With nitric acid; In trifluoroacetic acid; at 72 ℃; for 1.5h; regioselective reaction;
DOI:10.1021/op7001326

Reference yield:

: 863443-00-9
(4-fluorophenyl)[6-(methyloxy)-3-pyridinyl]methanol

: 863443-02-1
5-[(4-fluorophenyl)methyl]-3-nitro-2(1H)-pyridinone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane; chloro-trimethyl-silane; sodium iodide; trifluoroacetic acid / acetonitrile / 3 h / 70 °C

2: nitric acid / trifluoroacetic acid / 1.5 h / 72 °C

With triethylsilane; chloro-trimethyl-silane; nitric acid; trifluoroacetic acid; sodium iodide; In acetonitrile; trifluoroacetic acid;
DOI:10.1021/op7001326

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 863443-02-1
5-[(4-fluorophenyl)methyl]-3-nitro-2(1H)-pyridinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tert-butyl methyl ether; hexane / 1 h / -32 - -18 °C

1.2: 0.5 h / -23 °C

2.1: triethylsilane; chloro-trimethyl-silane; sodium iodide; trifluoroacetic acid / acetonitrile / 3 h / 70 °C

3.1: nitric acid / trifluoroacetic acid / 1.5 h / 72 °C

With triethylsilane; n-butyllithium; chloro-trimethyl-silane; nitric acid; trifluoroacetic acid; sodium iodide; In hexane; tert-butyl methyl ether; acetonitrile; trifluoroacetic acid;
DOI:10.1021/op7001326