863443-00-9Relevant academic research and scientific papers
A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2- pyridinecarboxylate
Boros, Eric E.,Burova, Svetlana A.,Erickson, Greg A.,Johns, Brian A.,Koble, Cecilia S.,Kurose, Noriyuki,Sharp, Matthew J.,Tabet, Elie A.,Thompson, James B.,Toczko, Matthew A.
, p. 899 - 902 (2007)
A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2- pyridinecarboxylate (1b), starting from 5-bromo-2-methoxypyridine (8) and 4-fluorobenzaldehyde (9), is described. Key steps in the process include lithium-bromine exchange of 8, addition of the
The Halogen–Samarium Exchange Reaction: Synthetic Applications and Kinetics
Anthore-Dalion, Lucile,Benischke, Andreas D.,Wei, Baosheng,Berionni, Guillaume,Knochel, Paul
supporting information, p. 4046 - 4050 (2019/02/26)
Fast I/Sm and Br/Sm exchanges take place when various aromatic or heterocyclic iodides and bromides are treated with nBu2SmCl?4 LiCl and nBu3Sm?5 LiCl, respectively. The resulting organosamarium reagents were efficiently quenched with aldehydes, ketones, and imines. Also, they undergo acylations when treated with N,N-dimethylamides leading to ketones. The rate of the Br/Sm exchange for a typical aryl bromide was determined and found to be 8.5×105 faster than the Br/Mg exchange, indicating that the rate of a metal-exchange is related to the ionic character of the carbon–metal bond and to the metal electronegativity.
HIV INTEGRASE INHIBITORS
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, (2015/09/22)
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
HIV INTEGRASE INHIBITORS
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Page/Page column 49-50, (2008/06/13)
The present infention features compounds that are HIV integrase inhibitors and may be useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
HIV INTEGRASE INHIBITORS
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Page/Page column 36, (2010/11/26)
The present infention features compounds that are HIV integrase inhibitors and may be useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
