2,4-DICHLORO-6-(TRIFLUOROMETHYL)-QUINAZOLINE

Base Information

• Chemical Name: 2,4-DICHLORO-6-(TRIFLUOROMETHYL)-QUINAZOLINE
• CAS No.: 864291-30-5
• Molecular Formula: C₉H₃Cl₂F₃N₂
• Molecular Weight: 267.037
• Mol file: 864291-30-5.mol

Synonyms:2,4-Dichloro-6-(trifluoromethyl)quinazoline;Quinazoline, 2,4-dichloro-6-(trifluoromethyl)-;LogP

Chemical Property of 2,4-DICHLORO-6-(TRIFLUOROMETHYL)-QUINAZOLINE

Chemical Property:

• Vapor Pressure: 0.152mmHg at 25°C
• Melting Point: 100.4-102.5 °C
• Refractive Index: 1.571
• Boiling Point: 222.3 °C at 760 mmHg
• PKA: -1.27±0.30(Predicted)
• Flash Point: 88.3 °C
• PSA: 25.78000
• Density: 1.595 g/cm³
• LogP: 3.95540

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-6-(trifluoromethyl)quinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-DICHLORO-6-(TRIFLUOROMETHYL)-QUINAZOLINE

There total 8 articles about 2,4-DICHLORO-6-(TRIFLUOROMETHYL)-QUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.79%

6-(trifluoromethyl)quinazoline-2,4(1H,3H)-dione (864291-33-8) → 2,4-dichloro-6-(trifluoromethyl)quinazoline (864291-30-5)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; at 120 ℃;

Reference yield: 46.0%

→ 2,4-dichloro-6-(trifluoromethyl)quinazoline (864291-30-5)

Guidance literature:

In acetonitrile; at 120 ℃;

Reference yield: 41.0%

2-amino-5-(trifluoromethyl)benzonitrile (6526-08-5) + trichloromethyl chloroformate (503-38-8) → 2,4-dichloro-6-(trifluoromethyl)quinazoline (864291-30-5)

Guidance literature:

In acetonitrile; at 130 ℃; for 12h;

DOI:10.1055/s-2005-922790

upstream raw materials:

2-amino-5-(trifluoromethyl)benzonitrile

trichloromethyl chloroformate

2,2,2-trifluoro-N-(2-iodo-4-(trifluoromethyl)phenyl)acetamide

4-trifluoromethylphenylamine