6526-08-5

Basic information

• Product Name: 2-Amino-5-trifluoromethylbenzonitrile
• Synonyms: 2-Amino-5-trifluoromethylbenzonitrile;4-Amino-3-cyanobenzotrifluoride;Benzonitrile, 2-aMino-5-(trifluoroMethyl)-;4-Amino-3-cyanobenzotrifluoride, 2-Cyano-4-(trifluoromethyl)aniline
• CAS NO: 6526-08-5
• Molecular Formula: C₈H₅F₃N₂
• Molecular Weight: 186.13
• Product Categories: Benzotrifluoride Series;Fluorine series
• Mol File: 6526-08-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 72-74 °C(Solv: benzene (71-43-2))
• Boiling Point: 95-115 C
• Flash Point: 116.189ºC
• Appearance: /
• Density: 1.371g/cm3
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.02±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5-trifluoromethylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-trifluoromethylbenzonitrile(6526-08-5)
• EPA Substance Registry System: 2-Amino-5-trifluoromethylbenzonitrile(6526-08-5)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 6526-08-5(Hazardous Substances Data)

Usage

General Description

2-Amino-5-trifluoromethylbenzonitrile is a chemical compound with the molecular formula C8H5F3N2. It is a white solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-Amino-5-trifluoromethylbenzonitrile is also known for its use in the production of dyes, pigments, and other organic compounds. 2-Amino-5-trifluoromethylbenzonitrile is a valuable building block in organic chemistry due to its versatile reactivity and ability to form a wide range of chemical bonds. It is important to handle this compound with care, as it can be harmful if ingested or inhaled, and may cause skin irritation upon contact.

InChI:InChI=1/C8H5F3N2/c9-8(10,11)6-1-2-7(13)5(3-6)4-12/h1-3H,13H2

Upstream product

• 878133-04-1 2,2,2-trifluoro-N-(2-iodo-4-(trifluoromethyl)phenyl)acetamide 
• 455-14-1 4-trifluoromethylphenylamine 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 75-05-8 acetonitrile 
• 544-92-3 copper(I) cyanide 
• 57946-63-1 4-amino-3-bromobenzotrifluoride 

Downstream Products

• 864291-30-5 2,4-dichloro-6-(trifluoromethyl)quinazoline 
• 1412905-10-2 N-(2-cyano-4-(trifluoromethyl)phenyl)-2-(2-oxo-2H-chromen-4-yloxy)propanamide 
• 133013-30-6 4-amino-3-bromo-5-cyano-trifluoromethylbenzene 
• 133013-29-3 2-amino-3-chloro-5-(trifluoromethyl)benzonitrile 
• 765297-88-9 2-amino-5-trifluorobenzylamine 
• 868166-20-5 2-iodo-5-(trifluoromethyl)benzonitrile 
• 6526-09-6 2-Amino-5-trifluormethylbenzothioamid 
• 58458-09-6 1,3-Bis(2-cyano-4-trifluormethylphenyl)triazen 
• 72773-39-8 2-(4-Nitro-2,6-bis-trifluoromethyl-phenylamino)-5-trifluoromethyl-benzonitrile 
• 72773-17-2 2-(2-Nitro-4,6-bis-trifluoromethyl-phenylamino)-5-trifluoromethyl-benzonitrile 
• 68105-74-8 2-(2,4-Dinitro-naphthalen-1-ylamino)-5-trifluoromethyl-benzonitrile 
• 1217302-05-0 ethyl [2-cyano-4-(trifluoromethyl)phenyl]carbamate 
• 864291-33-8 6-(trifluoromethyl)quinazoline-2,4(1H,3H)-dione 
• 57799-43-6 1-(2-amino-5-(trifluoromethyl)phenyl)ethanone 

Relevant articles and documents

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation

A palladium-catalyzed, norbornene-mediated ortho- and ipso-C-N bond-forming Catellani reaction is reported. This reaction proceeds through a sequential intermolecular amination followed by intramolecular cyclization of a tethered amide. The products, ortho-aminated dihydroquinolinones, were generated in moderate to good yields and are present in bioactive molecules. This work highlights the challenge of competing intra- vs intermolecular palladium-catalyzed processes.

Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein

Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. I