6526-08-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5-trifluoromethylbenzonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form a wide range of chemical bonds and contribute to the development of novel drug molecules with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Amino-5-trifluoromethylbenzonitrile is utilized as a building block in the production of agrochemicals, such as insecticides and herbicides, due to its versatile reactivity and potential to enhance the effectiveness of these compounds.
Used in Dye and Pigment Production:
2-Amino-5-trifluoromethylbenzonitrile is employed as a starting material in the synthesis of dyes and pigments, where its unique structure contributes to the development of new colorants with improved properties, such as enhanced color intensity and stability.
Used in Organic Chemistry Research:
As a valuable building block in organic chemistry, 2-Amino-5-trifluoromethylbenzonitrile is used in research to explore new synthetic pathways, develop novel compounds, and study the reactivity of its functional groups, contributing to the advancement of organic chemistry.
It is important to handle 2-Amino-5-trifluoromethylbenzonitrile with care, as it can be harmful if ingested or inhaled, and may cause skin irritation upon contact. Proper safety measures should be taken during its use to ensure the well-being of individuals and the environment.

InChI:InChI=1/C8H5F3N2/c9-8(10,11)6-1-2-7(13)5(3-6)4-12/h1-3H,13H2

Upstream product

• 544-92-3 copper(I) cyanide 
• 57946-63-1 4-amino-3-bromobenzotrifluoride 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 75-05-8 acetonitrile 
• 455-14-1 4-trifluoromethylphenylamine 
• 878133-04-1 2,2,2-trifluoro-N-(2-iodo-4-(trifluoromethyl)phenyl)acetamide 

Downstream Products

• 68105-74-8 2-(2,4-Dinitro-naphthalen-1-ylamino)-5-trifluoromethyl-benzonitrile 
• 72773-17-2 2-(2-Nitro-4,6-bis-trifluoromethyl-phenylamino)-5-trifluoromethyl-benzonitrile 
• 72773-39-8 2-(4-Nitro-2,6-bis-trifluoromethyl-phenylamino)-5-trifluoromethyl-benzonitrile 
• 864291-30-5 2,4-dichloro-6-(trifluoromethyl)quinazoline 
• 868166-20-5 2-iodo-5-(trifluoromethyl)benzonitrile 
• 765297-88-9 2-amino-5-trifluorobenzylamine 
• 875446-23-4 2-iodo-5-(trifluoromethyl)benzaldehyde 
• 1446786-09-9 2,4-diphenyl-6-(trifluoromethyl)quinazoline 
• 57799-43-6 1-(2-amino-5-(trifluoromethyl)phenyl)ethanone 
• 864291-33-8 6-(trifluoromethyl)quinazoline-2,4(1H,3H)-dione 
• 944158-29-6 (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-hydroxypropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one 
• 944158-28-5 (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(1-bromopropyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one 
• 944158-26-3 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzonitrile 
• 944158-27-4 (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

AMIDO COMPOUNDS AS AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation

A palladium-catalyzed, norbornene-mediated ortho- and ipso-C-N bond-forming Catellani reaction is reported. This reaction proceeds through a sequential intermolecular amination followed by intramolecular cyclization of a tethered amide. The products, ortho-aminated dihydroquinolinones, were generated in moderate to good yields and are present in bioactive molecules. This work highlights the challenge of competing intra- vs intermolecular palladium-catalyzed processes.

Copper-catalyzed oxidative cyanation of aryl halides with nitriles involving carbon-carbon cleavage

A novel, general route for the synthesis of aromatic nitriles is presented that proceeds through Cu(OAc)catalyzed oxidative cyanation of aryl halides using commercially available nitriles as the cyanide sources and Ag/air as the oxidizing agent. It is noteworthy that this work provides a new example of using acetonitrile as the cyanide source for aromatic nitrile synthesis through a Cu-catalyzed oxidative C-C bond cleavage and cyanation process.

Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein

Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. I

Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: Modifications of the oxazolidinone ring leading to the discovery of anacetrapib

The development of the structure-activity studies leading to the discovery of anacetrapib is described. These studies focused on varying the substitution of the oxazolidinone ring of the 5-aryloxazolidinone system. Specifically, it was found that substitution of the 4-position with a methyl group with the cis-stereochemistry relative to the 5-aryl group afforded compounds with increased cholesteryl ester transfer protein (CETP) inhibition potency and a robust in vivo effect on increasing HDL-C levels in transgenic mice expressing cynomolgus monkey CETP.

Design of a novel class of biphenyl CETP inhibitors

A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.

CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS

Compounds of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula

CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS

Compounds of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), A1 is a cyclic group, and B is a cyclic group which is attached to the heterocyclic ring directly or through a methylene group.

CETP INHIBITORS

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. The compounds have 3 cyclic groups connected by single bonds, as for example triphenyl, which are attached directly to the ring of formula I or attached at the position B.