Methanone, (2-chlorophenyl)[6-(2,4-difluorophenoxy)-4-fluoro-2-[[(2S)-2-hydroxyprop yl]amino]-3-pyridinyl]-

Base Information

Chemical Name:Methanone, (2-chlorophenyl)[6-(2,4-difluorophenoxy)-4-fluoro-2-[[(2S)-2-hydroxyprop yl]amino]-3-pyridinyl]-
CAS No.:864301-25-7
Molecular Formula:C21H16ClF3N2O3
Molecular Weight:436.818
Hs Code.:

Synonyms:

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Chemical Property of Methanone, (2-chlorophenyl)[6-(2,4-difluorophenoxy)-4-fluoro-2-[[(2S)-2-hydroxyprop yl]amino]-3-pyridinyl]-

Chemical Property:

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Technology Process of Methanone, (2-chlorophenyl)[6-(2,4-difluorophenoxy)-4-fluoro-2-[[(2S)-2-hydroxyprop yl]amino]-3-pyridinyl]-

There total 2 articles about Methanone, (2-chlorophenyl)[6-(2,4-difluorophenoxy)-4-fluoro-2-[[(2S)-2-hydroxyprop yl]amino]-3-pyridinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864301-24-6
(S)-(2-Chloro-phenyl)-[4,6-difluoro-2-(2-hydroxy-propylamino)-pyridin-3-yl]-methanone

: 864301-25-7
(S)-(2-Chloro-phenyl)-[6-(2,4-difluoro-phenoxy)-4-fluoro-2-(2-hydroxy-propylamino)-pyridin-3-yl]-methanone

Guidance literature:: 2,4-difluorophenol; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃;

(S)-(2-Chloro-phenyl)-[4,6-difluoro-2-(2-hydroxy-propylamino)-pyridin-3-yl]-methanone; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 864301-24-6
(S)-(2-Chloro-phenyl)-[4,6-difluoro-2-(2-hydroxy-propylamino)-pyridin-3-yl]-methanone

: 367-27-1
2,4-difluorophenol

: 864301-25-7
(S)-(2-Chloro-phenyl)-[6-(2,4-difluoro-phenoxy)-4-fluoro-2-(2-hydroxy-propylamino)-pyridin-3-yl]-methanone

Guidance literature:: 2,4-difluorophenol; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

(S)-(2-Chloro-phenyl)-[4,6-difluoro-2-(2-hydroxy-propylamino)-pyridin-3-yl]-methanone; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 864301-25-7
(S)-(2-Chloro-phenyl)-[6-(2,4-difluoro-phenoxy)-4-fluoro-2-(2-hydroxy-propylamino)-pyridin-3-yl]-methanone

: (S)-1-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-1H-pyrazolo[4,3-c]pyridin-4-ylamino]-propan-2-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; hydrazine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; at 90 ℃; for 6h;