2,4-Difluorophenol

Base Information

• Chemical Name: 2,4-Difluorophenol
• CAS No.: 367-27-1
• Molecular Formula: C6H4F2O
• Molecular Weight: 130.094
• Hs Code.: 29081000
• European Community (EC) Number: 206-688-0
• DSSTox Substance ID: DTXSID50190142
• Nikkaji Number: J193.876B
• Wikidata: Q72463644
• ChEMBL ID: CHEMBL395171
• Mol file: 367-27-1.mol

Synonyms:Phenol, 2,4-difluoro-;

Chemical Property of 2,4-Difluorophenol

Chemical Property:

• Appearance/Colour: clear yellow-green liquid after melting
• Melting Point: 22.4 °C(lit.)
• Refractive Index: n20/D 1.486(lit.)
• Boiling Point: 145.7 °C at 760 mmHg
• PKA: 8.72±0.18(Predicted)
• Flash Point: 56.7 °C
• PSA: 20.23000
• Density: 1.351 g/cm³
• LogP: 1.67040
• Storage Temp.: Flammables area
• Water Solubility.: slightly soluble
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 130.02302107
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi, C, F
• Hazard Codes: Xn,Xi,C,F
• Statements: 20/21/22-37/38-41-34-11-36/37/38
• Safety Statements: 26-36/37/39-45-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1F)F)O
• Uses: 2,4-Difluorophenol, is an organic building block used for the synthesis of various pharmaceutical compounds, such as antivirulence agents. It is also used in the synthesis of new α-Phenoxyacetamide derivatives, acting as type III secretion system of Pseudomonas aeruginosa PAO1, a gram-negative bacteria. 2,4-Difluorophenol has been used:as starting reagent during the synthesis of 4,6-difluoro-5,7-dihydroxytryptaminein the synthesis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), fluorinated fluorescent dye

Technology Process of 2,4-Difluorophenol

There total 18 articles about 2,4-Difluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

potassium (2,4-difluorophenyl)trifluoroborate → 2,4-difluorophenol (367-27-1)

Guidance literature:

With Oxone; water; In acetone; at 20 ℃; for 0.0333333h;

DOI:10.1021/jo102208d

Reference yield: 94.0%

para-difluorobenzene (540-36-3) → 2,4-difluorophenol (367-27-1) + 2,5-difluorophenol (2713-31-7)

Guidance literature:

With dihydrogen peroxide; In acetonitrile; at 60 ℃; for 0.416667h;

DOI:10.1021/ja505437h

Reference yield: 92.0%

2,4-difluorophenylboronic acid (144025-03-6) → 2,4-difluorophenol (367-27-1)

Guidance literature:

With dihydrogen peroxide; In water; at 20 ℃; chemoselective reaction;

DOI:10.1016/j.apcata.2018.05.037

upstream raw materials:

2,4-difluoro-1-methoxybenzene

2,4-difluorophenylamine

phenol

1,3-Difluorobenzene

Downstream raw materials:

3-(2,4-difluoro-phenoxy)-propionic acid

2-chloro-4,6-difluoro-phenol

2-bromo-4,6-difluorophenol

dichlorophosphoric acid-(2,4-difluoro-phenyl ester)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 367-27-1 2,4-Difluorophenol

Send

Send

Metric Ton KG G Pound L ML

Send

Send