2-Chloropurine

Base Information

• Chemical Name: 2-Chloropurine
• CAS No.: 1681-15-8
• Molecular Formula: C5H3ClN4
• Molecular Weight: 154.559
• Hs Code.: 2933990090
• Mol file: 1681-15-8.mol

Synonyms:1H-Purine,2-chloro- (9CI);NSC 17111;2-Chloropurine;Purine, 2-chloro- (7CI,8CI);

Chemical Property of 2-Chloropurine

Chemical Property:

• Vapor Pressure: 3.58E-06mmHg at 25°C
• Melting Point: 231-234 °C
• Refractive Index: 1.739
• Boiling Point: 397.7 °C at 760 mmHg
• PKA: 6.58±0.20(Predicted)
• Flash Point: 226.5 °C
• PSA: 54.46000
• Density: 1.653 g/cm³
• LogP: 1.00630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloropurine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloropurine

There total 8 articles about 2-Chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-chloro-6-thiopurine → 2-chloro-9H-purine (1681-15-8)

Guidance literature:

With nitric acid; In water; at 50 ℃; for 1h;

DOI:10.1080/10426507.2016.1225057

Reference yield: 75.0%

1-(2-chloro-9H-purin-6-yl)hydrazine (5404-88-6) → 2-chloro-9H-purine (1681-15-8)

Guidance literature:

With water; oxygen; copper(II) sulfate; at 80 ℃; for 6h; Green chemistry;

DOI:10.1039/c3gc41658e

Reference yield: 70.0%

2,6-dichloro-7H-purine (5451-40-1) → 2-chloro-7H-purine (1681-15-8)

Guidance literature:

DOI:10.1016/j.bmcl.2006.10.091

upstream raw materials:

2,6-dichloro-7H-purine

2-chloro-4,5-diaminopyrimidine

orthoformic acid triethyl ester

dimethoxymethyl acetate

Downstream raw materials:

2-chloro-9-(2,4-dichloro-benzyl)-9H-purine

2-chloro-7-(2,4-dichloro-benzyl)-7H-purine

[1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-(9H-purin-2-yl)-amine

tert-butyl (2-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate

Refernces

• 1、 Xia, Ran,Xie, Ming-Sheng,Niu, Hong-Ying,Qu, Gui-Rong,Guo, Hai-Ming. "Efficient synthesis of nebularine and vidarabine via dehydrazination of (hetero)aromatics catalyzed by CuSO4 in water". . p. 1077 - 1081. Retrieved 2014/03/21.
• 2、 Unciti-Broceta, Asier,Pineda De Las Infantas, Maria J.,Gallo, Miguel A.,Espinosa, Antonio. "Reduction of different electron-poor N-heteroarylhydrazines in strong basic conditions". . p. 1754 - 1762. Retrieved 2008/02/03.