Ethyl 3-(4-amino-2-fluorophenyl)prop-2-enoate

Base Information

Chemical Name:Ethyl 3-(4-amino-2-fluorophenyl)prop-2-enoate
CAS No.:865137-76-4
Molecular Formula:C11H12FNO2
Molecular Weight:209.22
Hs Code.:
DSSTox Substance ID:DTXSID80708178

Synonyms:Ethyl 4-amino-2-fluorocinnamate;Ethyl 3-(4-amino-2-fluorophenyl)prop-2-enoate;865137-76-4;ethyl 2-fluoro-4-aminocinnamate;DTXSID80708178;KCINNDBBSQBCEG-UHFFFAOYSA-N

Suppliers and Price of Ethyl 3-(4-amino-2-fluorophenyl)prop-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Ethyl 3-(4-amino-2-fluorophenyl)prop-2-enoate

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:209.08520679
Heavy Atom Count:15
Complexity:243

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C=CC1=C(C=C(C=C1)N)F

Technology Process of Ethyl 3-(4-amino-2-fluorophenyl)prop-2-enoate

There total 1 articles about Ethyl 3-(4-amino-2-fluorophenyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 656-65-5
3-fluoro-4-bromophenylamine

: 140-88-5,9003-32-1
ethyl acrylate

: 865137-76-4
ethyl (2E)-3-(4-amino-2-fluorophenyl)prop-2-enoate

Guidance literature:: With palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 110 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm2016123

Reference yield: 79.0%

: 865137-76-4
ethyl (2E)-3-(4-amino-2-fluorophenyl)prop-2-enoate

: 865137-77-5
ethyl 3-(4-amino-2-fluorophenyl)propanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; water; at 20 ℃; for 12h;
DOI:10.1021/jm2016123

Reference yield:

: 865137-76-4
ethyl (2E)-3-(4-amino-2-fluorophenyl)prop-2-enoate

: C₃₀H₃₄FNO₄

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; water / 12 h / 20 °C

2: toluene / 30 h / 20 °C / Molecular sieve

With palladium 10% on activated carbon; hydrogen; In ethanol; water; toluene;
DOI:10.1021/jm2016123