4-Ethynyl-2,6-dimethyl-pyridine

Base Information

• Chemical Name: 4-Ethynyl-2,6-dimethyl-pyridine
• CAS No.: 86520-95-8
• Molecular Formula: C9H9N
• Molecular Weight: 131.177
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80517606
• Nikkaji Number: J3.087.328I
• Wikidata: Q82379720
• Mol file: 86520-95-8.mol

Synonyms:4-ETHYNYL-2,6-DIMETHYL-PYRIDINE;86520-95-8;4-ethynyl-2,6-dimethylpyridine;SCHEMBL3720436;DTXSID80517606;GADAGOMYXYMHKZ-UHFFFAOYSA-N;AKOS006306656;CS-0236268;EN300-1699508

Chemical Property of 4-Ethynyl-2,6-dimethyl-pyridine

Chemical Property:

• PSA: 12.89000
• LogP: 1.67970
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 131.073499291
• Heavy Atom Count: 10
• Complexity: 143

Purity/Quality:

98%Min ^*data from raw suppliers

4-Ethynyl-2,6-dimethyl-pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=N1)C)C#C

Technology Process of 4-Ethynyl-2,6-dimethyl-pyridine

There total 9 articles about 4-Ethynyl-2,6-dimethyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,6-Dimethyl-4-trimethylsilanylethynyl-pyridine (86521-06-4) → 4-Ethynyl-2,6-dimethylpyridine (86520-95-8)

Guidance literature:

With potassium carbonate; In methanol; for 2h;

DOI:10.1039/c2dt30719g

Reference yield: 70.0%

4-(2,6-dimethylpyridin-4-yl)-2-methylbut-3-yn-2-ol (1215782-45-8) → 4-Ethynyl-2,6-dimethylpyridine (86520-95-8)

Guidance literature:

4-(2,6-dimethylpyridin-4-yl)-2-methylbut-3-yn-2-ol; With potassium hydroxide; In toluene; for 1h; Inert atmosphere; Reflux;

With water; In ethyl acetate; toluene; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2009.12.007

Reference yield:

C18H29NSi (1629603-21-9) → 4-Ethynyl-2,6-dimethylpyridine (86520-95-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0033-1340839

upstream raw materials:

2,6-Dimethyl-4-trimethylsilanylethynyl-pyridine

4-bromo-2,6-dimethylpyridine

4-(2,6-dimethylpyridin-4-yl)-2-methylbut-3-yn-2-ol

4-iodo-2,6-dimethylpyridine

Downstream raw materials:

1-(2,6-dimethylpyridin-4-yl)ethan-1-one

4-((3-bromophenyl)ethynyl)-2,6-dimethyIpyridine

[(2,6-Me₂)(4-(C₆F₅)3BCC)C₅H₂NH]

1,4-bis[(2,6-dimethylpyridin-4-yl)ethynyl]benzene

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