2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-

Base Information

Chemical Name:2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-
CAS No.:865305-30-2
Molecular Formula:C14H17IN4O2
Molecular Weight:400.219
Hs Code.:
ChEMBL ID:CHEMBL526307
DSSTox Substance ID:DTXSID90580447
Pharos Ligand ID:Q2DFSP4LT69F
Wikidata:Q27074324
Mol file:865305-30-2.mol

Synonyms:5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine;AF 353;AF-353;AF353 cpd

Suppliers and Price of 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
AF-353(Ro-4) >98%
1 g
$ 1400.00

DC Chemicals
AF-353(Ro-4) >98%
100 mg
$ 400.00

Crysdot
AF-353 98+%
5mg
$ 77.00

Crysdot
AF-353 98+%
10mg
$ 134.00

Crysdot
AF-353 98+%
50mg
$ 501.00

ChemScene
AF-353 98.95%
50mg
$ 435.00

ChemScene
AF-353 98.95%
25mg
$ 310.00

ChemScene
AF-353 98.95%
10mg
$ 155.00

ChemScene
AF-353 98.95%
5mg
$ 88.00

Cayman Chemical
AF-353
5mg
$ 102.00

Total 17 raw suppliers

Chemical Property of 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-

Chemical Property:

Boiling Point:510.2±60.0 °C(Predicted)
PKA:6.89±0.10(Predicted)
PSA：97.74000
Density:1.619±0.06 g/cm3(Predicted)
LogP:3.03010
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:400.03962
Heavy Atom Count:21
Complexity:334

Purity/Quality:

99% ^*data from raw suppliers

AF-353(Ro-4) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC
Description AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.

Technology Process of 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-

There total 3 articles about 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%